Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K [PDF]
, 2018 SMO (Smoothened), the central transducer of Hedgehog signaling, is coupled to heterotrimeric Gi proteins in many cell types, including cardiomyocytes.
Al-Owais, Moza +6 more
core +1 more source
Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5
Journal of Sleep Research, Volume 34, Issue 2, April 2025.Summary CDKL5 deficiency disorder is a rare genetic disease caused by mutations in the CDKL5 gene. Central apneas during wakefulness have been reported in patients with CDKL5 deficiency disorder. Studies on CDKL5‐knockout mice, a CDKL5 deficiency disorder model, reported sleep apneas, but it is still unclear whether these events are central (central ...
Gabriele Matteoli +12 more
wiley +1 more source
Retracted: Ginsenoside Rg3 Alleviates Antithyroid Cancer Drug Vandetanib-Induced QT Interval Prolongation. [PDF]
Oxid Med Cell Longev, 2023 Longevity OMAC.
europepmc +1 more source
QT Interval Evaluation in Right Ventricular Pacing: Validation of a Novel Formula
Pacing and Clinical Electrophysiology, EarlyView.Abstract Background QT interval measurement in the presence of right ventricular pacing (RVP) represents a clinical challenge. We therefore aimed to derive and validate a formula for QT estimation during RVP in a large cohort of pacemaker patients. Methods and Results We prospectively enrolled 100 patients in a derivation cohort and 487 in a validation
Amr Abdin +9 more
wiley +1 more source
Detection of QT interval prolongation using Apple Watch electrocardiogram in children and adolescents with congenital long QT syndrome. [PDF]
Int J Cardiol Heart Vasc, 2023 Yee-Ming Li J +5 more
europepmc +1 more source
Pacing and Clinical Electrophysiology, EarlyView.BiVP = biventricular pacing; CRT = cardiac resynchronization therapy; EMW = electromechanical window; LBBAP = left bundle branch area pacing; QAoC = Time interval from the onset of the QRS complex to the center of the aortic valve closure artifact; QT = QT interval measured by tangent method.
Florien Klein +18 more
wiley +1 more source
High-Throughput Assessment of Real-World Medication Effects on QT Interval Prolongation: Observational Study. [PDF]
JMIR Cardio, 2023 Yuan N +6 more
europepmc +1 more source
Antibiotic‐mediated immune modulation in periodontitis
Periodontology 2000, EarlyView.Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez +6 more
wiley +1 more source
Effects of adjunctive pimavanserin and current antipsychotic treatment on QT interval prolongation in patients with schizophrenia. [PDF]
Front Psychiatry, 2022 Bugarski-Kirola D +4 more
europepmc +1 more source
Water and Environment Journal, EarlyView.Tracer testing assessed hydraulics and nitrate removal in three full‐scale agricultural drainage treatment wetlands over 3.5 years (three tests). The first test showed rapid, short‐circuited flow and low residence time. After modifying the collection system, the second test increased residence time from 1 to 7 days.
Jan Kukačka +7 more
wiley +1 more source