Results 131 to 140 of about 24,231 (256)

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

QT Interval Prolongation in Chronic Liver Disease: A Cross-Sectional Study. [PDF]

Cureus
Venkata Harischandra T, Zulqurnain A, Irshad A, Arif M, Abdul Razzak A, Tayyab M, Rehman AU.   +6 more
europepmc   +1 more source

Physiological mechanisms underlying enhanced performance with blood flow restriction training: neuromuscular, vascular and metabolic adaptations

The Journal of Physiology, EarlyView.
Abstract figure legend We investigated how 6 weeks of dynamic knee‐extensor interval training with blood flow restriction (BFR‐leg) and without (CTRL‐leg) impacts performance and its mechanisms using non‐invasive methods. Specifically, we used gold‐standard methods to assess neuromuscular function, vascular function using Doppler ultrasound, and near ...
Colin Lavigne, Valentin Mons, Clément Lemineur, Oliver Meste, Georges Lefthériotis, Grégory M. Blain   +5 more
wiley   +1 more source

QT Interval Prolongation and Dementia in a General Japanese Population: the Hisayama Study. [PDF]

J Atheroscler Thromb
Mashima T, Oishi E, Honda T, Hata J, Minohara T, Ohara T, Nakao T, Kitazono T, Yamaura K, Ninomiya T.   +9 more
europepmc   +1 more source

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

QT interval prolongation in patients receiving bedaquiline-based regimens for drug-resistant tuberculosis in Sub-Saharan Africa: A systematic review and meta-analysis. [PDF]

J Clin Tuberc Other Mycobact Dis
Okello MO, Pitua I, Okema JN, Ekwem D, Bongomin F, Olum R.   +5 more
europepmc   +1 more source

Genetic and Molecular Aspects of Drug-Induced QT Interval Prolongation. [PDF]

Int J Mol Sci, 2021
Baracaldo-Santamaría D, Llinás-Caballero K, Corso-Ramirez JM, Restrepo CM, Dominguez-Dominguez CA, Fonseca-Mendoza DJ, Calderon-Ospina CA.   +6 more
europepmc   +1 more source

The interplay between dynamic regulation of ion‐channel gating and trafficking in cardiac arrhythmogenesis

The Journal of Physiology, EarlyView.
Abstract figure legend Cardiac cellular electrophysiology is modulated by multiple factors, including temperature, extracellular K+, heart rate/pacing frequency, and drugs. These modulators can have distinct effects on ion‐channel gating and transcription/trafficking over time.
Stefan Meier, Anna S. Savchenko, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Factors influencing QT interval prolongation during rifampicin-resistant tuberculosis treatment: a multicenter real-world study from China. [PDF]

BMC Infect Dis
Gao S, Zou L, Tang P, Pan Q, Liu Y, Kang W, Ma J, Chen Q, Shi Z, Tang X, Liang L, Guo C, Du J, Zhu Q, Yang S, Chang Z, Guo Z, Wu G, Tang S.   +18 more
europepmc   +1 more source

Heart rate-corrected QT interval prolongation is associated with decreased heart rate variability in patients with type 2 diabetes. [PDF]

Medicine (Baltimore), 2022
Cha SA.
europepmc   +1 more source