Results 151 to 160 of about 1,019,184 (189)
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QT Interval Prolongation: And the Beat Goes on
Mini-Reviews in Medicinal Chemistry, 2005Consideration of QT interval prolongation and the risk for developing torsade de pointes is a critical issue in the evaluation of new bioactive agents. Over the past several years, there has been a dramatic increase in understanding the I(Kr) channel and its role in the duration of the action potential and cardiac repolarization. Furthermore, a variety
Mehran, Jalaie, Daniel D, Holsworth
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In response to the prolonged QT interval and use of the TpTe interval…
The American Journal of Emergency Medicine, 2013We thank you for your feedback and commentary regarding our original submission. In response to the questions regarding measurements of QTc, it is our practice to manually measure the QT interval in cases where we are concerned, and we typically use the Bazett formula for calculation of the QTc.
Joshua B, Moskovitz +4 more
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QT-Interval Prolongation Produced by Probucol
Archives of Internal Medicine, 1981To the Editor. —Probucol (4,4′-[(1-methylethylidene) bis (thio)] bis [2,6-bis(1,1-dimethylethyl) phenol]) is a recently introduced drug for the lowering of serum cholesterol levels in familial hypercholesterolemia type II. 1,2 Side effects are considered slight, and no ECG abnormalities have been reported in humans receiving probucol. 2,3 This article
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Drug-Induced Prolongation of the QT Interval
New England Journal of Medicine, 2004The single most common cause of the withdrawal or restriction of the use of marketed drugs has been QT-interval prolongation associated with polymorphic ventricular tachycardia, or torsade de pointes, a condition that can be fatal. This review summarizes the current knowledge about molecular and clinical predictors of drug-induced QT-interval ...
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Low-Energy Diets and Prolonged QT Intervals
JAMA: The Journal of the American Medical Association, 1987To the Editor.— In a recent review entitled "Prolonged QT-Interval Syndromes," 1 the author indicates that "prolongation of the QT interval, malignant ventricular arrhythmias, and unexpected sudden death have been reported in patients who have lost considerable weight on the very-low-energy liquid protein diets." Dr Moss states that "sustained use of ...
S, Frank, J A, Colliver, A, Frank
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Is QT interval prolongation harmful? A regulatory perspective
The American Journal of Cardiology, 1993Drugs that prolong the QT interval may increase the risk of torsades de pointes, a potentially lethal ventricular arrhythmia. In recent years, spontaneous reports have highlighted these complications in patients receiving certain antihistamines (e.g., terfenadine or astemizole) or an agent for the treatment of incontinence (terodiline).
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Medications That Prolong the QT IntervalMedications That Prolong the QT Interval
JAMA, 2003openaire +2 more sources
Experimental QT Interval Prolongationa
Annals of the New York Academy of Sciences, 1992G, Malfatto +4 more
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