Results 81 to 90 of about 1,019,184 (189)

A randomized controlled trial of the short-term effect of rosuvastatin on the corrected QT interval

Scientific Reports
Rosuvastatin can block human ether-a-go-go related gene (hERG) currents and prolong the corrected QT (QTc) interval, but this effect has not been confirmed in the population.
Lijun Zhu, Wenjun Shen, Wanying Hu, Haiwang Guan, Yanwei Wang, Conglin Wang, Jing Lin, Li Chen, Qingjun Jiang   +8 more
doaj   +1 more source

Incidence of QT interval prolongation during arsenic trioxide-based therapy in a sample of Iraqi adult patients with acute promyelocytic leukemia (a single-center experience)

Iraqi Journal of Hematology
BACKGROUND: Arsenic trioxide (ATO) regimen is now the standard of care for acute promyelocytic leukemia (APL). The complete remission and possible cure are reported to be 50%–80% of APL patients.
Aseel Abd Ul Sahib Hassan, Ali M. Jawad Almothaffar   +1 more
doaj   +1 more source

QT PRODACT: In Vivo QT Assay in Anesthetized Dog for Detecting the Potential for QT Interval Prolongation by Human Pharmaceuticals

, 2005
The purpose of this study was to assess the utility of the isoflurane-anesthetized dog model for detecting the potential for QT interval prolongation by human pharmaceuticals.
Hiroyasu Miyazaki, Kumiko Aoki, Hiroyuki Tashibu, Yasuki Akie, Keiji Yamamoto   +4 more
core   +1 more source

QT prolongation due to targeted anticancer therapy [PDF]

, 2016
A growing number of targeted anticancer agents has shown the unexpected ability to induce QT interval prolongation. In addition, standard chemotherapeutics and a variety of conditions such as electrolyte abnormalities, endocrine disorders, cardiac ...
Bacharova, Ljuba, Setteyova, Lucia, Mladosievicova, Beata   +2 more
core  

Assessing QT interval prolongation and its associated risks with antipsychotics

, 2011
Several antipsychotics are associated with the ventricular tachycardia torsade de pointes (TdP), which may lead to sudden cardiac death (SCD), because of their inhibition of the cardiac delayed potassium rectifier channel.
Meyer, Jonathan M., Meyer, Jonathan M, David Taylor, Jimmi Nielsen, Jørgen K. Kanters, Nielsen, Jimmi, Jonathan M. Meyer, Taylor, David, Graff, Claus, Graff, Claus; id_orcid, Egon Toft, Kanters, Jørgen K., Toft, Egon, Claus Graff, Kanters, Jørgen K, Taylor, David; id_orcid   +15 more
core   +1 more source

A prospective study on change of QTc interval with antipsychotic medications in patients of schizophrenia and related psychotic disorder

Asian Journal of Medical Sciences
Background: Sudden unexplained death in individuals with mental health problems was described in 1960 and a link with antipsychotic drugs was postulated over 40 years ago.
Shaswata Mandal , Nitu Mallik , Rudraprasad Acharya , Manoj Kumar   +3 more
doaj   +1 more source

Assessment of the cardiac safety of prucalopride in healthy volunteers: a randomized, double-blind, placebo- and positive-controlled thorough QT study [PDF]

, 2012
Vandeplassche, L, Camm, J, Dennis O. Chanter, Kerstens, R, Lieve Vandeplassche, Jannie Ausma, Chanter, DO, Ausma, J, Boaz Mendzelevski, Mendzelevski, B, Patricia Robinson, Robinson, P, John Camm, Rene Kerstens   +13 more
core   +1 more source

SSRIs and QT interval prolongation management. A review

, 2017
IntroductionIn 2011, the FDA issued an alert recommending not to prescribe citalopram high doses, due to QT prolongation risk. We explored the clinical background of QT interval prolongation related to serotonin selective reuptake inhibitors (SSRI) use ...
H. Saiz, A. Portilla, L. Montes, R. Elorza, A. Ballesteros, Á.S. Rosero   +5 more
core   +1 more source

Evaluation of QT prolongation and arrhythmias in drug-resistant tuberculosis patients receiving bedaquiline-containing regimen: a prospective observational study in Eastern India

The Journal of Association of Chest Physicians
Background: Preliminary studies on bedaquiline (BDQ) for drug-resistant tuberculosis (DR-TB) treatment have shown variable incidences of QT interval changes.
S. Raghul Raj, Rupam Kumar Ta, Sandip Mukhopadhyay   +2 more
doaj   +1 more source

Studies of in vivo drug-induced QT interval prolongation in early-stage drug development

, 2010
The potential for non-cardiac drugs to induce QT interval prolongation accompanied by a rare but life-threatening lethal arrhythmia has generated intense interest and concern in the development of pharmaceuticals.
田保, 充康
core   +1 more source