Results 71 to 80 of about 1,019,184 (189)

Drug-Induced Proarrhythmia: QT Interval Prolongation and Torsades de Pointes [PDF]

, 2011
Drug-induced torsades de pointes (TdP), a life-threatening polymorphic ventricular tachycardia associated with prolongation of the QT interval, has been the main safety reason for the withdrawal of non-cardiac agents from clinical use over the last ...
Tsikrikas, Spyros, Letsas, Konstantinos, Letsas, George P, Sideris, Antonios   +3 more
core   +1 more source

Mechanisms, Risk Factors, and Management of Acquired Long QT Syndrome: A Comprehensive Review

The Scientific World Journal, 2012
Long QT syndrome is characterized by prolongation of the corrected QT (QTc) interval on the surface electrocardiogram and is associated with precipitation of torsade de pointes (TdP), a polymorphic ventricular tachycardia that may cause sudden death ...
Eleftherios M. Kallergis, Christos A. Goudis, Emmanuel N. Simantirakis, George E. Kochiadakis, Panos E. Vardas   +4 more
doaj   +1 more source

Effect of intravenous ondansetron on QT interval prolongation in patients with cardiovascular disease and additional risk factors for torsades: a prospective, observational study

, 2011
Matthew J Hafermann1, Rocsanna Namdar2, Gretchen E Seibold2,3, Robert Lee Page 2nd2,31University of Washington Medical Center, Department of Pharmacy, Seattle, WA; 2University of Colorado Anschutz Medical Campus, School of Pharmacy, Aurora, CO ...
Seibold GE, Hafermann MJ, Namdar R, Page RL 2nd   +3 more
core  

Drug-Induced QT Prolongation

, 2014
Abnormal cardiac repolarization, as indicated by prolongation of the QT interval on the standard electrocardiogram, is a risk factor for malignant dysrhythmias such as torsades de pointes.
Jackie V. Abadie, Adam M. Kaye, Kaye, Adam M., Elizabeth A. Valentine, Abadie, Jackie V., Alan David Kaye, Kaye, Alan D., Valentine, Elizabeth A.   +7 more
core   +1 more source

Propranolol can correct prolonged QT intervals in patients with cirrhosis

Frontiers in Pharmacology
Background:Prolonged QT intervals are extremely common in patients with cirrhosis and affect their treatment outcomes. Propranolol is often used to prevent gastroesophageal variceal hemorrhage in patients with cirrhosis; however, it is uncertain whether ...
Huanqin Han, Junlian Chen, Zhirong Deng, Tingting Li, Xiaoying Qi, Wei Deng, Zunge Wu, Chuli Xiao, Weiqiang Zheng, Yujun Du   +9 more
doaj   +1 more source

Drug-Induced QT Prolongation as a Result of an Escitalopram Overdose in a Patient with Previously Undiagnosed Congenital Long QT Syndrome

Case Reports in Medicine, 2014
We present a case of drug-induced QT prolongation caused by an escitalopram overdose in a patient with previously undiagnosed congenital LQTS. A 15-year-old Caucasian female presented following a suicide attempt via an escitalopram overdose.
Paul Singh, J. Martin Maldonado-Duran
doaj   +1 more source

Autonomic and sensory nerve dysfunction in primary biliary cirrhosis [PDF]

, 2004
AIM: Cardiovascular autonomic and peripheral sensory neuropathy is a known complication of chronic alcoholic and non-alcoholic liver diseases. We aimed to assess the prevalence and risk factors for peripheral sensory nerve and autonomic dysfunction using
Horváth, Andrea, Lakatos, Péter László, Csák, Tímea, Szalay, Ferenc, Istenes, Ildikó, Varga, Péter, Kempler, Péter, Keresztes, Katalin, Folhoffer, Anikó   +8 more
core   +1 more source

Effect of artemisinin-piperaquine treatment on the electrocardiogram of malaria patients

Revista da Sociedade Brasileira de Medicina Tropical, 2019
INTRODUCTION: Concern regarding the cardiotoxicity of antimalarials has been renewed because of their potential to cause QT/QTc interval prolongation related to torsade de pointes (TdP).
Wanting Wu, Yuan Liang, Guangchao Wu, Yinghang Su, Hongying Zhang, Zhenyan Zhang, Changsheng Deng, Qi Wang, Bo Huang, Bo Tan, Chongjun Zhou, Jianping Song   +11 more
doaj   +1 more source

Measurement and Management of QT Interval Prolongation for General Physicians

, 2020
One of the more challenging aspects of ECG interpretation is measurement and interpretation of the QT interval. This interval represents the time taken for the ventricles to completely repolarise after activation. Abnormal prolongation of the QT interval
Szirt, Richard, Indraratna, Praveen, Tardo, Daniel, Delves, Madeline, Ng, Ben   +4 more
core   +1 more source

Issues in QT interval measurement

Indian Pacing and Electrophysiology Journal, 2004
The QT interval, apart from clinical implications is crucial for safety assessment of new drugs under development. A QTc prolongation of even 10 msec in a study group is a warning signal for a new drug.
Pallavi Lanjewar, Vaishali Pathak, Yash Lokhandwala   +2 more
doaj