Results 131 to 140 of about 55,181 (324)

QT prolongation predicts short-term mortality independent of comorbidity [PDF]

, 2019
Charlotte Gibbs, Jacob Thalamus, Doris Tove Kristoffersen, Martin Veel Svendsen, Øystein L. Holla, Kristian Heldal, Kristina H. Haugaa, Jan Hysing   +7 more
openalex   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Convergence and optimality of the adaptive nonconforming linear element method for the Stokes problem

, 2013
In this paper, we analyze the convergence and optimality of a standard adaptive nonconforming linear element method for the Stokes problem. After establishing a special quasi--orthogonality property for both the velocity and the pressure in this saddle ...
Hu, Jun, Xu, Jinchao
core   +1 more source

Yield of Whole Genome Sequencing for Pathogenic Single Nucleotide Variants in Congenital Heart Disease: A Systematic Review and Meta‐Analysis

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to assess the diagnostic yield of pathogenic or likely pathogenic (P/LP) single nucleotide variants (SNVs) using whole genome sequencing (WGS) in congenital heart disease (CHD). Methods A systematic search of three databases (2000–2024) was conducted, and two reviewers independently ...
Hiba J. Mustafa, Parisa Najjariasl, Faezeh Aghajani, Enaja V. Sambatur, Andrew Rodenbarger, Stephanie Guseh, Amy E. Roberts, Alireza A. Shamshirsaz   +7 more
wiley   +1 more source

Intervalo QT em doentes com hipertensão arterial: estudo por electrocardiograma [PDF]

, 2011
A hipertensão arterial (HTA) é um grave problema de saúde pública que afecta milhares de pessoas em todo o mundo. Apresenta uma elevada prevalência nas sociedades modernas, sendo um importantíssimo factor de risco para as doenças cardiovasculares.
Coelho, Patrícia, Pereira, Alexandre, Pereira, Telmo, Robalo, Diogo   +3 more
core  

Fr\"olicher-smooth geometries, quantum jet bundles and BRST symmetry

, 2014
We attempt a clarification of geometric aspects of quantum field theory by using the notion of smoothness introduced by Fr\"olicher and exploited by several authors in the study of functional bundles. A discussion of momentum and position representations
Canarutto, Daniel
core   +1 more source

A Mini Review of Scientific Designs of Dynamic Responsive Fluids in Battery Technologies

Rare Metals, EarlyView.
ABSTRACT Dynamic responsive fluids are emerging as transformative elements in the evolution of battery technologies, marking a pivotal shift from static passive designs toward systems that actively sense and adapt to their operating environments. By integrating dynamic responsive fluids, batteries can interact with both internal and external stimuli in
Xiu‐Zhen Yang, Ke‐Hao Wan, Yan‐Yun Wang, Song‐Ding‐Fan Lin, Xiao‐Wei Shen, Bo Zhou, Yu‐Xiang Chang, Peng‐Cheng Zhang, Jin‐Qiu Zhou, Jia‐Bao Li, Cheng‐Lin Yan, Tao Qian   +11 more
wiley   +1 more source

Cabergoline Induced Supraventricular Tachycardia with QT Prolongation [PDF]

, 2017
Vineetha Menon, Bhanuvaishnavi Gaddipati, Venkatesh Chandrasekaran, Pratibha Pereira, Hathur Basavanna Gowdappa, Madhan Ramesh   +5 more
openalex   +1 more source

The role of M cells and the long QT syndrome in cardiac arrhythmias: simulation studies of reentrant excitations using a detailed electrophysiological model

, 2004
In this numerical study, we investigate the role of intrinsic heterogeneities of cardiac tissue due to M cells in the generation and maintenance of reentrant excitations using the detailed Luo-Rudy dynamic model. This model has been extended to include a
Cherry E. M., Diego J. M. D., Hervé Henry, Wouter-Jan Rappel   +3 more
core   +1 more source

Additive Manufacturing of Hot‐Work Tool Steel by In Situ Alloying Using Laser Powder Bed Fusion and Directed Energy Deposition—Strategies to Improve Chemical Homogeneity

steel research international, EarlyView.
To support future alloy development a powder mixture is processed by laser additive manufacturing. The powder mixture containing Mo‐ and W‐rich tracers is processed by powder bed fusion using single and double laser exposure and by directed energy deposition which provides drastically enlarged melt pools.
Felix Großwendt, Sebastian Weber, Jonathan Lentz   +2 more
wiley   +1 more source