Results 151 to 160 of about 55,181 (324)

Facilitation of I Kr current by some hERG channel blockers suppresses early afterdepolarizations. [PDF]

, 2019
Drug-induced block of the cardiac rapid delayed rectifying potassium current (I Kr), carried by the human ether-a-go-go-related gene (hERG) channel, is the most common cause of acquired long QT syndrome.
Chen, I-Shan, Furutani, Kazuharu, Handa, Kenichiro, Kurachi, Yoshihisa, Sack, Jon T, Tsumoto, Kunichika, Yamakawa, Yuko   +6 more
core   +1 more source

Drug-Induced QT Prolongation: Individual Susceptibility and Regulatory Issues Related to Safety Pharmacology 5. QT Interval: Gender and Other Affecting Factors in the Clinical Setting

, 2006
Tetsunori Saikawa
openalex   +2 more sources

Mitochondrial Ca2+ overload is a pivotal risk factor for lethal ventricular arrhythmias due to the oxidation of mitochondrial respirasome and energetic failure

British Journal of Pharmacology, EarlyView.
The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions. Background and Purpose Ventricular arrhythmias are a leading cause of death among patients with cardiovascular diseases and are associated with elevated ...
Felipe de Jesús Salazar‐Ramírez, Luis Alberto Luévano‐Martínez, Abraham Méndez‐Fernández, Judith Bernal‐Ramírez, Carolina A. Morales‐Ochoa, Christian Silva‐Platas, Alfredo Cabrera‐Orefice, Ana C. Murrieta, José Luis Velasco‐Bolom, Gricelda Mendiola‐Garza, Flavio Contreras‐Torres, Guillermo Torre‐Amione, Ernesto A. Aiello, Gerardo García‐Rivas   +13 more
wiley   +1 more source

Corrected QT Interval Prolongation Complicating Incoercible Vomiting in a Coronavirus Disease 2019 Patient Under Chloroquine and Azithromycin

, 2020
Houda Nassih, Karima El Fakiri, Rabiy El Qadiry, Aïcha Bourrahouat, Imane Ait Sab   +4 more
openalex   +1 more source

Microtubule Inhibitors Induce Cross‐Resistance to Osimertinib Through CaMKII Activation in EGFR‐Mutated NSCLC

Cancer Science, EarlyView.
Eighteen‐week treatment with microtubule inhibitors induces resistance to osimertinib in EGFR‐mutated NSCLC cells. Vinorelbine‐ and paclitaxel‐resistant cells showed activation of FZD7 and CaMKII and increased sensitivity to CaMKII inhibition, with additive or synergistic effects when combined with osimertinib.
Kento Kono, Ryosuke Tanino, Yukari Tsubata, Eshat Fahmida Haque, Takeshi Isobe, Tamio Okimoto   +5 more
wiley   +1 more source

Chronic pentamidine aerosol prophylaxis does not induce QT-prolongation and vetricular arrythmias [PDF]

, 1993
Bogner, Johannes R., Lohmöller, G., Thalhammer, C.   +2 more
core   +1 more source

Erythromycin Shortage in an NTM‐Endemic Country: Implications for Bronchiectasis Care and Antimicrobial Stewardship

Respirology, EarlyView.
Takanori Asakura, Ho Namkoong
wiley   +1 more source

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, EarlyView.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source

Trazodone Overdose Manifesting as Hypotension and QT Prolongation. [PDF]

Cureus, 2023
Mohan G, Ajitkumar A, Bhide P, Ravilla J, Kramer V.   +4 more
europepmc   +1 more source

Lack of QT Prolongation for 2′-O-Methoxyethyl-Modified Antisense Oligonucleotides Based on Retrospective Exposure/Response Analysis of Ten Phase 1 Dose-Escalation Placebo-Controlled Studies in Healthy Subjects [PDF]

, 2017
Rosie Z. Yu, Rudy Gunawan, Richard S. Geary, Steven G. Hughes, Scott P. Henry, Yanfeng Wang   +5 more
openalex   +1 more source