Results 131 to 140 of about 30,871 (260)

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Lascufloxacin-Induced QT Prolongation in an Elderly Patient Treated With Escitalopram: A Case Report. [PDF]

Cureus
Koide T, Ito H, Ohashi R, Maekawa E, Ito K.   +4 more
europepmc   +1 more source

Quizartinib Resistance Mutations and Treatment Outcomes in Relapsed or Refractory FLT3‐ITD–Positive AML

Cancer Science, EarlyView.
ABSTRACT Quizartinib is a FMS‐like tyrosine kinase 3 (FLT3) inhibitor indicated for FLT3 internal tandem duplication (FLT3‐ITD)–positive acute myeloid leukemia (AML). We aimed to evaluate quizartinib resistance mechanisms, in addition to efficacy and safety outcomes, in patients with relapsed or refractory FLT3‐ITD–positive AML.
Yuichiro Semba, Toshihiro Miyamoto, Senji Kasahara, Yoshikane Kikushige, Takahiro Maeda, Goichi Yoshimoto, Shuichi Ota, Akio Saito, Yuho Najima, Hiroki Hosoi, Daigo Niiya, Koji Kato, Koji Nagafuji, Takashi Akasaka, Tomohiko Kamimura, Atsushi Takita, Maiko Narahara, Tadashi Toki, Koichi Iwanaga, Koji Yonemoto, Mine Harada, Koichi Akashi   +21 more
wiley   +1 more source

Aging-Induced QT Prolongation as a Potential Contributor to Longevity. [PDF]

J Cardiovasc Dev Dis
Rabkin SW.
europepmc   +1 more source

Pharmacological and non‐pharmacological interventions for managing sleep disorders in children with cerebral palsy: A systematic review

Developmental Medicine &Child Neurology, EarlyView.
xxxxxx Aim To systematically review the effectiveness, safety, and economic evidence of pharmacological and non‐pharmacological interventions for sleep disorders in children with cerebral palsy (CP). Method Databases including MEDLINE, Embase, CENTRAL (the Cochrane Library), International Clinical Trials Registry Platform of the World Health ...
Nishant Jaiswal, Lizzie Fisher, Giorgio Ciminata, Ryan Mulholland, Anna Noel‐Storr, Lesley Nutton, Valerie Orr, Paul Eunson, Nicola J. Cooper, Alex Sutton, Olivia Wu, Terry Quinn   +11 more
wiley   +1 more source

QT prolongation alerts lead to monitoring but rarely to therapeutic changes: a prospective hospital study. [PDF]

Front Pharmacol
Simona A, Lourenço T, Lovis C, Zekry D, Hannouche D, Vernaz N, Samer CF.   +6 more
europepmc   +1 more source

Hypoglycaemia care: Time to modernise our treatment standards

Diabetic Medicine, EarlyView.
This editorial argues that hypoglycaemia self care should move beyond ‘any sugar will do’ and define what good recovery after treatment should involve. It proposes recovery‐focused standards using CGM metrics, such as time‐in‐range and repeat lows after treatment, alongside participant‐reported recovery, so existing and emerging approaches, including ...
David Russell‐Jones, Julia K. Mader
wiley   +1 more source

QT Prolongation, Ventricular Arrhythmia, and Cardiac Arrest Signals During Ceftriaxone Co-therapy with Individual Proton Pump Inhibitors: A Multidatabase Study. [PDF]

Cardiovasc Toxicol
Chen Y, Gu Q, Zhao M, Zhao A, Kong Z, Shen H, Zhang Y, Wang S, Li L, Xie H, Liu P, Zhang H, Chen D.   +12 more
europepmc   +1 more source

Intravenous Oxytocin Does Not Affect Glucose‐Regulating Hormones or Markers of Bone Turnover During Graded Glucose Infusion in Healthy Men

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim Oxytocin has been proposed to exert glucose‐stabilising effects via modulation of pancreatic hormone secretion and to play a role in bone homeostasis. However, human data under controlled conditions are limited. We investigated the effects of intravenously infused oxytocin during a graded glucose infusion on glucose‐regulating hormones and
Vivian Kliim‐Hansen, Ida M. Gether, Aliya M. Thomas, Anne‐Marie Ellegaard, Miriam G. Pedersen, Jens J. Holst, Bolette Hartmann, Filip K. Knop, Lærke S. Gasbjerg, Asger B. Lund   +9 more
wiley   +1 more source

Adrenaline-induced hypokalemia and critical QT prolongation in a patient with refractory anaphylactic shock complicated by myocardial ischemia: a case report. [PDF]

Ann Med Surg (Lond)
Wada C, Sekino M, Shintani R, Kaneko S, Yokoyama A, Kasai Y, Iwasaki N, Araki H, Yano R, Ichinomiya T, Higashijima U, Hara T.   +11 more
europepmc   +1 more source