Results 41 to 50 of about 143,558 (182)

Potential QT-prolonging drug-drug interactions in cardiovascular disease patients [PDF]

Brazilian Journal of Pharmaceutical Sciences
The study aimed to assess the prevalence and characteristics of potential drug-drug interactions (pDDIs) that increase the risk of QT prolongation, in a population of cardiovascular disease patients.
Milena Kovačević, Milica Ćulafić, Marija Jovanović, Sandra Vezmar Kovačević, Katarina Vučićević, Branislava Miljković, Predrag Stevanović, Slavica Radovanović   +7 more
doaj   +1 more source

Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials

BMC Pharmacology and Toxicology, 2016
Proarrhythmia assessment is one of the major concerns for regulatory bodies and pharmaceutical industry. ICH guidelines recommending preclinical tests have been established in attempt to eliminate the risk of drug-induced arrhythmias.
B. Wiśniowska, Zofia Tylutki, Gabriela Wyszogrodzka, S. Polak   +3 more
semanticscholar   +1 more source

A real-world pharmacovigilance study of drug-induced QT interval prolongation: analysis of spontaneous reports submitted to FAERS

Frontiers in Cardiovascular Medicine
PurposeTo identify the most commonly reported drugs associated with QT interval prolongation in the FDA Adverse Event Reporting System (FAERS) and evaluate their risk for QT interval prolongation.MethodsWe employed the preferred term (PT ...
Haowen Tan, Haowen Tan, Xida Yan, Ying Chen, Guili Huang, Luping Luo, Wenjun Li, Weiwei Lan, Cheng Chen, Xin Xi   +9 more
doaj   +1 more source

Risk of QT prolongation and torsade de pointes associated with exposure to hydroxyzine: re‐evaluation of an established drug

Pharmacology Research & Perspectives, 2017
Several noncardiac drugs have been linked to cardiac safety concerns, highlighting the importance of post‐marketing surveillance and continued evaluation of the benefit‐risk of long‐established drugs.
A. Schlit, A. Delaunois, A. Colomar, Branderley Claudio, L. Cariolato, R. Boev, J. Valentin, Christopher Peters, V. Sloan, J. Bentz   +9 more
semanticscholar   +1 more source

QT prolongation is associated with increased mortality in end stage liver disease

World Journal of Cardiology, 2017
AIM To determine the prevalence of QT prolongation in a large series of end stage liver disease (ESLD) patients and its association to clinical variables and mortality.
S. M. Kim, Bennet George, Diego Alcivar-Franco, C. Campbell, R. Charnigo, B. Delisle, J. Hundley, Yousef H Darrat, G. Morales, S. Elayi, A. Bailey   +10 more
semanticscholar   +1 more source

Nonalcoholic Fatty Liver Disease Is Associated With QT Prolongation in the General Population

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2015
Background Nonalcoholic fatty liver disease (NAFLD) is independently associated with QT prolongation among patients with diabetes. It has not yet been determined whether this association remains valid in the general population.
C. Hung, P. Tseng, C. Tu, C. Chen, Wei-Chih Liao, Yi-Chia Lee, Han-Mo Chiu, Hung-Ju Lin, Y. Ho, Wei-Shiung Yang, Ming-Shiang Wu, Ming‐Fong Chen   +11 more
semanticscholar   +1 more source

QT Interval Revisited —Not Just the Matter of “Interval,” but “Dynamics, Variability and Morphology” Matter!—

Journal of Arrhythmia, 2007
Recently, the effects of QT interval prolongation have received more attention among clinicians, industry, and official regulatory agencies. Some have advocated the total elimination or discontinuing development of drugs which prolong the QT interval. In
Tetsunori Saikawa, MD, Mikiko Nakagawa, MD, Naohiko Takahashi, MD   +2 more
doaj   +1 more source

Macrolide Antibiotic Mediated Cardiac Arrhythmias: Emerging Concepts and Clinical Implications

Biomedicines
The macrolide class of antibiotics are widely utilized in clinical settings for a broad range of bacterial infections and have additional roles as immunomodulatory agents. Although efficacious with a good safety profile overall, they have been associated
Fatima Iqbal, Alyssa Derouen, Robin Ren, Adam M. Kaye, Shahab Ahmadzadeh, Sahar Shekoohi, Alan D. Kaye   +6 more
doaj   +1 more source

Mechanisms, Risk Factors, and Management of Acquired Long QT Syndrome: A Comprehensive Review

The Scientific World Journal, 2012
Long QT syndrome is characterized by prolongation of the corrected QT (QTc) interval on the surface electrocardiogram and is associated with precipitation of torsade de pointes (TdP), a polymorphic ventricular tachycardia that may cause sudden death ...
Eleftherios M. Kallergis, Christos A. Goudis, Emmanuel N. Simantirakis, George E. Kochiadakis, Panos E. Vardas   +4 more
doaj   +1 more source

Risk assessment of drug-induced QT prolongation.

Australian Prescriber, 2015
Drugs can cause prolongation of the QT interval, alone or in combination, potentially leading to fatal arrhythmias such as torsades de pointes. When prescribing drugs that prolong the QT interval, the balance of benefit versus harm should always be ...
G. Isbister
semanticscholar   +1 more source