Results 11 to 20 of about 90,562 (356)
The power of QTL mapping with RILs. [PDF]
PLoS ONE, 2012 QTL (quantitative trait loci) mapping is commonly used to identify genetic regions responsible to important phenotype variation. A common strategy of QTL mapping is to use recombinant inbred lines (RILs), which are usually established by several ...
Shohei Takuno +2 more
doaj +4 more sources
Behavior Genetics, 2004 The standard variance components method for mapping quantitative trait loci is derived on the assumption of normality. Unsurprisingly, statistical tests based on this method do not perform so well if this assumption is not satisfied. We use the statistical concept of copulas to relax the assumption of normality and derive a test that can perform well ...
Basrak, B. +4 more
openaire +5 more sources
R/qtl: high-throughput multiple QTL mapping [PDF]
Bioinformatics, 2010 AbstractMotivation: R/qtl is free and powerful software for mapping and exploring quantitative trait loci (QTL). R/qtl provides a fully comprehensive range of methods for a wide range of experimental cross types. We recently added multiple QTL mapping (MQM) to R/qtl.
Danny Arends +3 more
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QTL Mapping Under Ascertainment [PDF]
Annals of Human Genetics, 2006 SummaryMapping quantitative trait loci (QTL) using ascertained sibships is discussed. It is shown that under the standard normality assumption of variance components analysis the efficient scores are unchanged by ascertainment, and two different schemes of ascertainment correction suggested in the literature are asymptotically equivalent.
J, Peng, D, Siegmund
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Human QTL linkage mapping [PDF]
Genetica, 2008 Human quantitative trait locus (QTL) linkage mapping, although based on classical statistical genetic methods that have been around for many years, has been employed for genome-wide screening for only the last 10-15 years. In this time, there have been many success stories, ranging from QTLs that have been replicated in independent studies to those for
Laura, Almasy, John, Blangero
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Trends in Genetics, 1995 In the past 10 years, interest in applying the tools of molecular genetics to the problem of increasing world rice production has resulted in the generation of two highly saturated, molecular linkage maps of rice, and the localization of numerous genes and quantitative trait loci (QTLs).
S R, McCouch, R W, Doerge
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A robust QTL mapping procedure [PDF]
Journal of Statistical Planning and Inference, 2009 In quantitative-trait linkage studies using experimental crosses, the conventional normal location-shift model or other parameterizations may be unnecessarily restrictive. We generalize the mapping problem to a genuine nonparametric setup and provide a robust estimation procedure for the situation where the underlying phenotype distributions are ...
Zou, Fei +3 more
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Target Enrichment Improves Mapping of Complex Traits by Deep Sequencing
G3: Genes, Genomes, Genetics, 2016 Complex traits such as crop performance and human diseases are controlled by multiple genetic loci, many of which have small effects and often go undetected by traditional quantitative trait locus (QTL) mapping.
Jianjun Guo +3 more
doaj +1 more source
QTL linkage analysis of connected populations using ancestral marker and pedigree information [PDF]
, 2012 The common assumption in quantitative trait locus (QTL) linkage mapping studies that parents of multiple connected populations are unrelated is unrealistic for many plant breeding programs.
Bink, M.C.A.M. +5 more
core +2 more sources
QTL Mapping to QTL Cloning: Mice to the Rescue [PDF]
Genome Research, 1997 With the availability of dense, highly informative marker maps, it has recently become feasible to map genes (Quantitative Trait Loci or QTL) accounting for part of the heritability of continuously distributed traits in experimental crosses as well as outbred populations. QTL mapping efforts have almost invariably revealed a limited number of loci with
openaire +3 more sources