Results 11 to 20 of about 2,184 (94)

Exploring the Impact of Ultrasonic Activation on the Antimicrobial Activity of Root Canal Sealers: A Year‐Long Ex Vivo Investigation Into Bacterial Survival

International Endodontic Journal, EarlyView.
ABSTRACT Aim This study investigated the long‐term survival of bacteria in root canals obturated using two endodontic sealers—AH Plus Jet (AHP) and BioRoot RCS (BCS)—while also assessing the influence of ultrasonic agitation on their antimicrobial effectiveness.
F. L. P. Viana, M. A. F. Damasceno, M. P. Alcalde, R. R. Vivan, I. G. de Moraes, M. A. H. Duarte, E. T. Pinheiro, B. C. Vasconcelos   +7 more
wiley   +1 more source

Histopathological and Molecular Data on Myxobolus spp. Infecting Bryconid Fish From the Brazilian Pantanal Wetland

Journal of Fish Diseases, EarlyView.
ABSTRACT Previous studies described Myxobolus umidus infecting the spleen of Brycon hilarii, whereas Myxobolus pantanalis and Myxobolus salminus infecting the gill filaments of Salminus brasiliensis. In this study, we provided supplementary morphological and molecular data on these three Myxobolus species and histopathological analyses of the tissues ...
Caroline Munhoz Meira, Milena Lucia Cornejo, Sarah Arana, Edson Aparecido Adriano, Antonio Augusto Mendes Maia   +4 more
wiley   +1 more source

Galectin‐3 plasma levels are associated with left atrial contractile function in long‐distance runners

Experimental Physiology, EarlyView.
Abstract High‐intensity endurance exercise induces myocardial remodelling as an adaptive response to sustained volume overload, but excessive cumulative training might also favour deleterious cardiac remodelling, including atrial fibrosis. Whether acute marathon running engages circulating fibrosis‐related biomarkers and whether these biomarkers track ...
Felipe Contreras‐Briceño, Fernanda Sanhueza‐Olivares, Rodrigo Fernández, Silvana Llevaneras, Pablo F. Castro, Luigi Gabrielli, Mario Chiong   +6 more
wiley   +1 more source

Methamphetamine Enantiomers: From Chemical Synthesis to Biological Fate

Chirality, Volume 38, Issue 9, September 2026.
Methamphetamine is an amphetamine‐type stimulant characterized by a single stereogenic center, resulting in two enantiomers, (R)‐(−)‐methamphetamine and (S)‐(+)‐methamphetamine, with distinct biological and pharmacological profiles. These forms exhibit differences in central nervous system activity, metabolism, excretion, and overall physiological ...
Larissa Pires do Espírito Santo, Renato Lúcio de Carvalho, Juliana Almeida Sad, Pedro Henrique Costa dos Santos, Rhaiza Silva Domingues, Gabriele de Azevedo Cardoso, Karine Braga Enes, Gisele Assis Castro Goulart, Maila de Castro Lourenço das Neves, Ângelo de Fátima   +9 more
wiley   +1 more source

Topliss‐Guided Optimization of Acetanilide‐Based Soluble Epoxide Hydrolase Inhibitors: Exploring the Pentafluorosulfanyl Group as a Potency‐Enhancing Motif

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Can an amide analog retain the high potency of the classic urea motif in soluble epoxide hydrolase inhibitors? Through a single unconventional switch, the introduction of the underexplored pentafluorosulfanyl group into an amide analog of TPPU, the authors restored high inhibitory potency.
Alba López‐Ruiz, Eugènia Pujol, Cristian Ramos, Valeria Rizzo, Christophe Morisseau, Cristina Val, Tiziana Ginex, Javier Vázquez, Sandra Codony, Andreea L. Turcu, Belén Pérez, Elena Sáez, Antonio Pineda‐Lucena, Bruce D. Hammock, F. Javier Luque, M. Isabel Loza, José Brea, Santiago Vázquez   +17 more
wiley   +1 more source

A Macrocyclic Bistriazene: Stabilization of the [Ni(Py)2]2+ Complex Cation with 6,15,23,32−Tetraethoxycarbonyl−bis(tolanetriazenediide) Ion as Ligand

Zeitschrift für anorganische und allgemeine Chemie, Volume 652, Issue 12, 3 August 2026.
The arrangement of the complex molecules [Ni((4,4′−EtO(CO)2tolaneN3)2(py)2] and pyridine as crystallization solvate in the solid state based on nonbonded intermolecular interactions such CH⋅⋅⋅py, CH⋅⋅⋅O and CH⋅⋅⋅HC contacts is discussed in this work.
Aline Joana Rolina Wohlmuth Alves dos Santos, Johannes Beck, Manfredo Hörner, Daniel Felipe Pietezak, Robson da Silva Oliboni, Petra Krieger‐Beck, Gertrud Dittmann   +6 more
wiley   +1 more source

Human Leukocyte Elastase Triggered Nanoparticles for Targeted Antimicrobial Delivery and Oral Microbial Modulation

Advanced NanoBiomed Research, Volume 6, Issue 8, August 2026.
This study explores enzyme‐responsive nanoparticles for targeted antimicrobial release in inflamed oral environments. Nanoparticles formed by complexing peptides and chlorhexidine respond to human leukocyte elastase and release chlorhexidine selectively. P7 (ECAAPVCE)‐based formulations show optimal properties and stability, with antimicrobial activity
Mohammed A. Hadis, Ignacio Insua, Farah N. S. Raja, Álvaro Vila, William M. Palin, Michael R. Milward, Paul R. Cooper, Sarah A. Kuehne, Owen Addison, Paco Fernandez‐Trillo   +9 more
wiley   +1 more source

Estrogen Receptor Beta Activation Coordinates Liver Lipid Remodeling and Metabolic Fluxes, Preventing Lipotoxicity

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
ERβ activation restores glucose and lipid homeostasis by remodeling the hepatic lipidome. Mechanistically, it promotes complete fatty acid oxidation and decreases Acetyl‐CoA levels, leading to reduced ketogenesis and lipotoxicity, as demonstrated through in vivo and in vitro approaches.
Debora Santos Rocha, Eloisa Vilas‐Boas, Camille C. Caldeira da Silva, Everton L. Vogt, Marcos Yoshinaga, Mariana Pacheco Teixeira de Carvalho, Maiara I. C. Queiroz, Tiago Eugênio Oliveira da Silva, Sayuri Miyamoto, Alicia J. Kowaltowski   +9 more
wiley   +1 more source

Immunoglobulin binding protein (BiP) forms two types of dimers

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Immunoglobulin binding protein (BiP) is a chaperone protein that plays crucial roles in protein folding and transport by binding unfolded proteins in the substrate binding domain (SBD), an interaction allosterically linked to the nucleotide occupancy of the nucleotide binding domain (NBD).
Karina New, Miguel I. A. Lagos‐Espinoza, Nathalie Casanova‐Morales, Roi Asor, John William Young, Zahra Alavi, Christian A. M. Wilson   +6 more
wiley   +1 more source

Exploring Biological Properties of Manganese(II)‐Phenanthroline‐Based Complexes: In Vitro Insights

ChemistrySelect, Volume 11, Issue 29, 3 August 2026.
Four Mn(II) complexes with phenanthroline derivatives were studied. These compounds were tested against several parasites and different human cancer cells. Despite its cytotoxicity on breast cancer, DNA seems not to be the main biological target. These complexes can drive the design and development of new metal‐based agents with improved biological ...
Roberto S. Silva, Marcos V. Palmeira‐Mello, Mikaelly P. Caet, Celisnolia M. Leite, Arieli B. Portugal, Pedro H. Machado, Alexandre B. Carvalho, Isabel Correia, Leonardo M. Moreira, Thatiana L. B. V. Simão, Elena Lasunskaia, Michelle F. Muzitano, José L. Nepomuceno‐Silva, João L. M. Wanderley, Javier Ellena, Alzir A. Batista, Mario S. Schultz   +16 more
wiley   +1 more source