Results 11 to 20 of about 150,397 (174)

Bile acids: Lipase-catalyzed synthesis of new hyodeoxycholic acid derivatives [PDF]

, 2018
In this work we present an efficient, environmentally friendly approach to the synthesis of a series of hyodeoxycholic acid derivatives applying Biocatalysis.
Baldessari, Alicia, Chanquia, Santiago Nahuel, Garcia Liñares, Guadalupe Eugenia, Ripani, Erika Aldana   +3 more
core   +1 more source

Synthesis of Combretastatin A-4 and 3′-Aminocombretastatin A-4 derivatives with Aminoacid Containing Pendants and Study of their Interaction with Tubulin and as Downregulators of the VEGF, hTERT and c-Myc Gene Expression

Molecules, 2020
Natural product combretastatin A-4 (CA-4) and its nitrogenated analogue 3′-aminocombretastatin A-4 (AmCA-4) have shown promising antitumor activities.
Raül Agut, Eva Falomir, Juan Murga, Celia Martín-Beltrán, Raquel Gil-Edo, Alberto Pla, Miguel Carda, J. Alberto Marco   +7 more
doaj   +1 more source

Gas Chromatography-Mass Spectrometry Study of the Essential Oils of Schinus longifolia (Lindl.) Speg., Schinus fasciculata (Griseb.) I. M. Johnst., and Schinus areira L. [PDF]

, 2005
The essential oil composition from the aerial parts of three Anacardiaceae growing in Bah¨ªa Blanca, Argentina was studied by gas chromatography and gas chromatography-mass spectrometry. The essential oils of S. longifolia and S.
Frontera, Maria Eugenia, Mulet, María Cristina, Murray, Ana Paula, Tomas, María A.   +3 more
core   +1 more source

Volatiles from Subtropical Convolvulaceae That Interfere with Bacterial Cell-to-Cell Communication as Potential Antipathogenic Drugs [PDF]

, 2016
Increasing chronic bacterial infections create an urgent need for new antimicrobial agents or strategies for their control. Targetingvirulence is one of the alternative approaches to find new medicines to treat persistent infections due to bacteria with ...
Arena, Mario Eduardo, Bardon, Alicia del Valle, Cartagena, Elena, Luciardi, María Constanza, Muruaga, Nora, Pérez Hernández, María Victoria   +5 more
core   +4 more sources

Reaction of benzoxasilocines with aromatic aldehydes: Synthesis of homopterocarpans

Beilstein Journal of Organic Chemistry, 2007
Condensation of 2H-benzo[g][1,2]oxasilocines with aromatic aldehydes in the presence of boron trifluoride affords mixtures of cis/trans 2-phenyl-3-vinylchromans with moderate yields.
Míriam Álvarez-Corral, Cristóbal López-Sánchez, Leticia Jiménez-González, Antonio Rosales, Manuel Muñoz-Dorado, Ignacio Rodríguez-García   +5 more
doaj   +1 more source

Derivatives of grindelic acid: from a non-active natural diterpene to synthetic antitumor derivatives [PDF]

, 2013
Using several reactions that include homologations and asymmetric epoxidations as well as Ugi and Huisgen couplings, we generated a small focused library of new derivatives from the labdane-type diterpene grindelic acid. These compounds were evaluated as
Chiaramello, Alejandra Ilda, Donadel, Osvaldo Juan, García, Celina, León, Leticia G., Martín, Victor S., Padrón, José M., Reta, Guillermo Federico, Tonn, Carlos Eugenio   +7 more
core   +3 more sources

Binding-driven reactivity attenuation enables NMR identification of selective drug candidates for nucleic acid targets

Communications Chemistry, 2022
NMR spectroscopy could be a robust and reliable method for binding detection in drug discovery, but DNA/RNA targets remain challenging to analyze. Here, the authors explore the perturbation of the ligand reactivity caused by complex formation as a ...
Laura Díaz-Casado, Andrés G. Santana, Irene Gómez-Pinto, Alejandro Villacampa, Francisco Corzana, Jesús Jiménez-Barbero, Carlos González, Juan Luis Asensio   +7 more
doaj   +1 more source

Multicomponent synthesis of 4,4-dimethyl sterol analogues and their effect on eukaryotic cells [PDF]

, 2014
Most sterols, such as cholesterol and ergosterol, become functional only after the removal of the two methyl groups at C-4 from their biosynthetic precursors.
Alonso, Fernando, Barquero, Andrea Alejandra, Cabrera, Gabriela Myriam, Cirigliano, Adriana Monica, Davola, Maria Eugenia, Garcia Liñares, Guadalupe Eugenia, Labriola, Carlos Alberto, Ramirez, Javier Alberto   +7 more
core   +1 more source

Chemoenzymatic Synthesis of Triazololactams Structurally Related to Pancratistatin [PDF]

, 2017
Four tricyclic lactams that structurally resemble alkaloids with the pancratistatin skeleton were synthetized from bromobenzene by a chemoenzymatic strategy.
Bastida, Bellomo, Bellomo, Bellomo, Bellomo, Bellomo, Brovetto, Brovetto, Cao, Carless, Carrau, Carrera, Carrera, Chrétien, Desjardins, Ghavre, Gibson, Gibson, Goietsenoven, Griffen, Griffin, He, Hudlicky, Hudlicky, Hudlicky, Hudlicky, Kolb, Kornienko, la Sovera, la Sovera, la Sovera, Labora, Lamoral-Theys, Ma, Ma, Ma, McNulty, Plietker, Rinner, Staudinger, Thevenet, Tian, Vila, Vshyvenko, Vshyvenko, Vshyvenko, Vshyvenko, Wu, Yadav   +48 more
core   +1 more source

Synthetic scope and DFT analysis of the chiral binap–gold(I) complex-catalyzed 1,3-dipolar cycloaddition of azlactones with alkenes

Beilstein Journal of Organic Chemistry, 2013
The 1,3-dipolar cycloaddition between glycine-derived azlactones with maleimides is efficiently catalyzed by the dimeric chiral complex [(Sa)-Binap·AuTFA]2.
María Martín-Rodríguez, Luis M. Castelló, Carmen Nájera, José M. Sansano, Olatz Larrañaga, Abel de Cózar, Fernando P. Cossío   +6 more
doaj   +1 more source