Results 11 to 20 of about 7,051 (128)

Synthesis of Combretastatin A-4 and 3′-Aminocombretastatin A-4 derivatives with Aminoacid Containing Pendants and Study of their Interaction with Tubulin and as Downregulators of the VEGF, hTERT and c-Myc Gene Expression

Molecules, 2020
Natural product combretastatin A-4 (CA-4) and its nitrogenated analogue 3′-aminocombretastatin A-4 (AmCA-4) have shown promising antitumor activities.
Raül Agut, Eva Falomir, Juan Murga, Celia Martín-Beltrán, Raquel Gil-Edo, Alberto Pla, Miguel Carda, J. Alberto Marco   +7 more
doaj   +1 more source

Reaction of benzoxasilocines with aromatic aldehydes: Synthesis of homopterocarpans

Beilstein Journal of Organic Chemistry, 2007
Condensation of 2H-benzo[g][1,2]oxasilocines with aromatic aldehydes in the presence of boron trifluoride affords mixtures of cis/trans 2-phenyl-3-vinylchromans with moderate yields.
Míriam Álvarez-Corral, Cristóbal López-Sánchez, Leticia Jiménez-González, Antonio Rosales, Manuel Muñoz-Dorado, Ignacio Rodríguez-García   +5 more
doaj   +1 more source

Synthesis of Pterocarpans

Natural Product Communications, 2011
The total synthesis of natural pterocarpans and analogs is reviewed.
Leticia Jiménez-González, Carmen Hernández-Cervantes, Míriam Álvarez-Corral, Manuel Muñoz-Dorado, Ignacio Rodríguez-García   +4 more
doaj   +1 more source

Binding-driven reactivity attenuation enables NMR identification of selective drug candidates for nucleic acid targets

Communications Chemistry, 2022
NMR spectroscopy could be a robust and reliable method for binding detection in drug discovery, but DNA/RNA targets remain challenging to analyze. Here, the authors explore the perturbation of the ligand reactivity caused by complex formation as a ...
Laura Díaz-Casado, Andrés G. Santana, Irene Gómez-Pinto, Alejandro Villacampa, Francisco Corzana, Jesús Jiménez-Barbero, Carlos González, Juan Luis Asensio   +7 more
doaj   +1 more source

Synthetic scope and DFT analysis of the chiral binap–gold(I) complex-catalyzed 1,3-dipolar cycloaddition of azlactones with alkenes

Beilstein Journal of Organic Chemistry, 2013
The 1,3-dipolar cycloaddition between glycine-derived azlactones with maleimides is efficiently catalyzed by the dimeric chiral complex [(Sa)-Binap·AuTFA]2.
María Martín-Rodríguez, Luis M. Castelló, Carmen Nájera, José M. Sansano, Olatz Larrañaga, Abel de Cózar, Fernando P. Cossío   +6 more
doaj   +1 more source

π‐Enlargement in Porphyrin Macrocycles at Interfaces

Angewandte Chemie, EarlyView.
On‐surface synthesis of a 20‐π free‐base expanded porphyrin, by depositing onto a hot Ag(111) substrate an 18‐π free‐base precursor equipped with ‐CF3 functional groups ABSTRACT Porphyrins are essential heteroatomic macrocycles, fundamental to both biological systems and advanced technology.
Ana Barragán, Elena Pérez‐Elvira, Alba García‐Frutos, Diego J. Vicent, Pingo Mutombo, Koen Lauwaet, José M. Gallego, Rodolfo Miranda, José I. Urgel, Aurelio Gallardo, Nazario Martín, David Écija   +11 more
wiley   +2 more sources

A Convenient Synthesis of the Central Core of Helioporins, -Pseudopterosins and Pseudopterosins BCA-Annulation Sequence

Natural Product Communications, 2008
A convenient synthesis of the central core of helioporins, seco -pseudopterosins and pseudopterosins in racemic form is reported, using a Suzuki coupling (A-ring formation)-Friedel-Crafts acylation sequence, followed by synthetic elaboration of the ...
Gema Esteban, Rocío Rincón, Aurelio G. Csákÿ, Joaquín Plumet   +3 more
doaj   +1 more source

Removing lead from water with carboxylate dendrimers and magnetic nanoparticles modified with carboxylate dendrimers

Applied Water Science, 2023
Contamination of water with heavy metals as lead (Pb2+) is a relevant problematic issue. In this work, we have tested different types of dendritic materials for lead removal from water and further recovery. The systems employed are magnetic nanoparticles
David Rincón-Montón, David Martínez-Salvador, Javier Sánchez-Nieves, Rafael Gómez, F. Javier de la Mata, Jesús Cano   +5 more
doaj   +1 more source

A Deep‐Red‐Absorbing Osmium(II) Complex as a Photosensitizer for Photodynamic Therapy Inducing Immunogenic Cell Death

Angewandte Chemie, EarlyView.
A deep‐red‐excited osmium(II) photosensitizer (Os2) induces immunogenic cell death (ICD) under 740 nm irradiation and triggers robust anti‐tumor immune responses both in vitro and in vivo. ABSTRACT Immunogenic cell death (ICD), which converts tumor cells into their own vaccine, plays a pivotal role in the development of novel anticancer therapies. Here,
Yiyi Zhang, Pierre Mesdom, Eduardo Izquierdo‐García, João P. M. António, Ruonan Gao, Bruno Saubaméa, Johanne Seguin, Morgane Moinard, Philippe Arnoux, Céline Frochot, Kevin Cariou, Bich‐Thuy Doan, Gilles Gasser   +12 more
wiley   +2 more sources

Nanoscale Biocompatible Structures Generated from Fluorinated Tripodal Phenylenes on Gold Nanoprisms

ChemistryOpen, 2022
Modification of gold substrates with a stable, uniform and ultrathin layer of biocompatible materials is of tremendous interest for the development of bio‐devices.
Prof. Dr. Miguel García‐Castro, Prof. Dr. Ana Moscoso, Prof. Dr. Francisco Sarabia, Prof. Dr. Juan Manuel López‐Romero, Prof. Dr. Rafael Contreras‐Cáceres, Prof. Dr. Amelia Díaz   +5 more
doaj   +1 more source