Results 171 to 180 of about 4,094,105 (298)

MethyAnno: An Interpretable Automated Annotation Method Leveraging Multi‐Scale Information and Metric Learning Framework for scDNAm Data

open access: yesAdvanced Science, EarlyView.
MethyAnno enables robust and interpretable annotation of single‐cell DNA methylation data by integrating multi‐scale epigenetic information, bidirectional cross‐attention, and prototype‐based metric learning. The framework resolves rare and novel cell types across datasets while revealing cell‐type‐specific epigenetic signatures associated with disease
Yuhang Jia   +4 more
wiley   +1 more source

Uniqueness Conditions for the Infinite-Planning Horizon Open-Loop Linear Quadratic Differential Game [PDF]

open access: yes
In this note we consider the open-loop Nash linear quadratic differential game with an infinite planning horizon.The performance function is assumed to be indefinite and the underlying system affine.We derive both necessary and sufficient conditions ...
Engwerda, J.C.
core  

Functional–Taxonomic Scaling Resolves Conflicting Average Genome Size Estimates Across Environmental Gradients

open access: yesAdvanced Science, EarlyView.
Based on genome size‐functional breadth theory, we introduce and validate a framework that adjudicates conflicting average genome size (AGS) estimates by testing which estimate yields a gap between scaled functional diversity and scaled taxonomic diversity that is consistent with the expected positive association between genome size and gene functional
Huanhuan Zhu   +8 more
wiley   +1 more source

A Result on Output Feedback Linear Quadratic Control [PDF]

open access: yes
In this note we consider the static output feedback linear quadratic control problem.We present both necessary and sufficient conditions under which this problem has a solution in case the involved cost depend only on the output and control variables ...
Weeren, A.J.T.M., Engwerda, J.C.
core  

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

open access: yesAdvanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka   +10 more
wiley   +1 more source

Algorithms in the theory of integral binary quadratic forms [PDF]

open access: yes
The classical ("old fashioned") theory of integral binary quadratic forms was developed by Gauss in his famous "Disquisitiones Arithmeticae". This thesis is concerned with the formal description and analysis of a selection of algorithms which make ...
Iliopoulos, C. S. (Costas S.)
core  

Green's Functions of Non‐Hermitian Systems at Exceptional Deficiency

open access: yesAdvanced Science, EarlyView.
We analyze the responses of a non‐Hermitian lattice system under the condition of exceptional deficiency (ED), when all bands in the system are formed by exceptional points. Using the frequency domain, we identify novel steady‐state responses that root in the broadband super‐Lorentzian Green's function (GF).
Congwei Lu, Guancong Ma
wiley   +1 more source

The Open-Loop Discounted Linear Quadratic Differential Game for Regular Higher Order Index Descriptor Systems [PDF]

open access: yes
In this paper we consider the discounted linear quadratic differential game for descriptor systems that have an index larger than one. We derive both necessary and sufficient conditions for existence of an open-loop Nash (OLN) equilibrium.
Salmah, Y.   +2 more
core  

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