Results 51 to 60 of about 1,774,533 (302)
Arthritis Care &Research, EarlyView.Objective Obesity, defined by body mass index (BMI) ≥30 kg/m2, is a risk factor for functional limitations in people with knee osteoarthritis (OA). However, function varies among such individuals. Our objective was to evaluate the implications of obesity subtypes on longitudinal patterns of physical functioning in people with or at risk for knee OA ...
Kristine Godziuk +7 more
wiley +1 more source
BMC Musculoskeletal Disorders, 2020 Background Muscle weakness is an important etiological factor in plantar fasciitis (PF), but available data on the role of the quadriceps, hamstring, and gastrocnemius (GCM) muscles are limited.
Jin Hyuck Lee +2 more
doaj +1 more source
Determination of a Critical Size Threshold for Volumetric Muscle Loss in the Mouse Quadriceps
Tissue Engineering. Part C, Methods, 2019 Skeletal muscle has a remarkable regenerative capacity; however, after volumetric muscle loss (VML) or a loss of a large portion of the tissue, this regenerative response is diminished and results in chronic functional deficits.
Shannon E. Anderson +11 more
semanticscholar +1 more source
Advanced Robotics Research, EarlyView.This study presents a soft pneumatic fabric bidirectional actuation module (PNEUMA) capable of generating high torque in both bending directions within a single integrated architecture. PNEUMA achieves up to 50 Nm with reduced inflation volume and a lightweight design.
Odysseas Simatos +2 more
wiley +1 more source
Advanced Science, EarlyView.In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang +19 more
wiley +1 more source
Eccentric/Concentric Torque Deficits in the Quadriceps Muscle [PDF]
Journal of Orthopaedic & Sports Physical Therapy, 1989 The purpose of the present investigation was to estimate the percentage of asymptomatic subjects who demonstrate an eccentric/concentric torque deficit in leg extension. One hundred and five subjects with a mean age of 23.51 were tested on the KIN-COM(R) dynamometer for maximum eccentric and concentric torque during leg extension using an 80 degrees ...
Trudelle-Jackson, Elaine +3 more
openaire +3 more sources
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Journal of the American Medical Association (JAMA), 2018 Importance Early in-bed cycling and electrical muscle stimulation may improve the benefits of rehabilitation in patients in the intensive care unit (ICU).
G. Fossat +15 more
semanticscholar +1 more source
Advanced Science, EarlyView.Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai +16 more
wiley +1 more source
Journal of Strength and Conditioning Research, 2018 Risberg, MA, Steffen, K, Nilstad, A, Myklebust, G, Kristianslund, E, Moltubakk, MM, and Krosshaug, T. Normative quadriceps and hamstring muscle strength values for female, healthy, elite handball and football players. J Strength Cond Res 32(8): 2314–2323,
M. Risberg +6 more
semanticscholar +1 more source