Results 81 to 90 of about 4,909 (260)

Introduction of a Double‐Headed Nucleotide Into G‐Quadruplex DNA: Position‐Dependent Stabilization and Structural Insights

Chemistry – A European Journal, EarlyView.
A double‐headed bis‐guanine (G) nucleotide (GG) was evaluated as a noncanonical building block in G‐quadruplexes (G4s). Biophysical and computational analyses reveal that GG can directly participate in G‐tetrads and strongly stabilize G4s in a position‐ and topology‐dependent manner. These findings establish design rules for using GG to engineer highly
Krista Urup, Peter Reinholdt, Kasper Munch Beck, Michael Petersen, Jean‐Louis Mergny, Poul Nielsen   +5 more
wiley   +1 more source

Drivers and challenges of RIS3‐related university engagement: Insights from five European regions

Regional Science Policy &Practice, EarlyView., 2022
Abstract Universities have long been considered key players in regional innovation systems and innovation‐driven regional development. In addition, as part of the quadruple helix, they can play a major role in RIS3 design and implementation by acting as civic universities.
Sabrina Tomasi, Petra Szávics, Chiara Aleffi, Concetta Ferrara, András Márton, Nataša Urbančíková, Patrice dos Santos, Ana Ribeiro, Alessio Cavicchi, Oto Hudec   +9 more
wiley   +1 more source

Strategic Planning in Polish Municipalities and the Quadruple Helix Approach: An Analysis of the Relationship Between Local Stakeholder Involvement and Strategy Development Methods

Quaestiones Geographicae
This article focuses on the tools used in the strategic planning process and the involvement of various stakeholder groups based on the results of a survey. A computer-assisted web interview (CAWI) survey was conducted for the purposes of this study.
Dziemianowicz Wojciech, Cybulska Magdalena, Stokowski Michał   +2 more
doaj   +1 more source

Raman Optical Activity as a Tool to Monitor Polynucleotide Conformation in Solutions

Chemistry – A European Journal, EarlyView.
Raman optical activity (ROA) studies of nucleic acids have been hindered by limited computational tools to link the spectra to the structure. The study shows that accurate density functional simulations are possible for model nucleotides, bringing more information about molecular geometry and dynamics in solutions.
Mohammed Siddhique Para Kkadan, Josef Kapitán, Jiří Kessler, Ondřej Zapletal, Valery Andrushchenko, Petr Bouř   +5 more
wiley   +1 more source

Quadruple helix collaboration for eHealth: a business relationship approach

International Journal of Healthcare Technology and Management
Collaboration between various stakeholders is crucial for healthcare digitalisation and eHealth utilisation. Given that valuable outcomes can emerge from collaborative interactions among multiple stakeholders, exploring a quadruple helix (QH) approach to collaboration may be fruitful in involving the public sector, business, citizens, and academia ...
Qvarfordt, Maria, Lagrosen, Stefan, Nilsson, Lina   +2 more
openaire   +3 more sources

Synergistic Optical Strategies for Enhanced Perovskite Photocatalytic Activity

EcoEnergy, EarlyView.
This review addresses bottlenecks of halide perovskites' photoactive components from an optics‐driven perspective and organizes recent advances into four interconnected design principles. This review provides practical design principles and outlines key directions toward efficient, selective, and stable perovskite photocatalysis for CO2 reduction ...
Jaemin Jeong, Myeongjin Seol, Sang Hyun Ahn, Soo Young Kim   +3 more
wiley   +1 more source

Fabrication of flexible composite electrodes and their application in flexible supercapacitors for wearable electronic devices

FlexMat, EarlyView.
This review surveys current progress in composite flexible electrodes for flexible supercapacitors, emphasizing how structural engineering and material synergy enhance both mechanical compliance and electrochemical performance. It discusses fabrication strategies, emerging application scenarios, and ongoing challenges, offering updated insights that ...
Weikang Wang, Qing Liu, Ang Lv, Shuai Zhou, Chunlei Zhang, Luping Zhang, Liming Li, Weiwei Zhao, Yuchun Tang, Fei Huang   +9 more
wiley   +1 more source

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Production of recombinant human granulocyte‐macrophage colony‐stimulating factor in thermoinducible E. coli: Tuning inclusion body architecture and protein yield via dissolved oxygen control

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Recombinant protein expression in Escherichia coli frequently results in the formation of inclusion bodies (IBs), which provide high protein accumulation but often require additional steps to recover functional protein. Although culture conditions strongly influence IB physicochemical and structural characteristics, the impact of ...
Ximena Gómez‐Gil, Norma A Valdez‐Cruz, Sara Restrepo‐Pineda, Nuria Sánchez‐Puig, Rafael Vázquez‐Duhalt, Rubén D Cadena‐Nava, Néstor O Pérez, Mauricio A Trujillo‐Roldán   +7 more
wiley   +1 more source

Is Early Marriage a Problem in Indonesia? Maqāṣid Al-Sharī‘ah, Economic and Quadruple Helix Analysis

Afkaruna: Indonesian Interdisciplinary Journal of Islamic Studies
Early marriage is a contributing factor to low levels of health, education, and family welfare. Early marriage is a worldwide occurrence that warrants the attention of all stakeholders, including UNICEF.
Yusup Hidayat, Aris Machmud, Sadino Sadino, Anas Lutfi, Prosper Maguchu   +4 more
doaj   +1 more source