Results 151 to 160 of about 165,724 (306)

Current status of breast cancer diagnosis and treatment capacity in county-level medical institutions in Sichuan Province, China: a cross-sectional study. [PDF]

Front Oncol
Kang L, Du C, Huang Y, Chen H, Tan X.
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The Qualifications and Credit Framework : an introduction for sector skills councils, standards setting bodies and the education sector

, 2009
The QCF: • recognises smaller steps of learning and enables learners to build up qualifications bit by bit • helps learners achieve skills and qualifications that meet industry needs • involves a wider range of awarding organisations, including ...

core  

Data resource profile: education and health data in New Zealand's Integrated Data Infrastructure. [PDF]

Int J Popul Data Sci
Schober T, Bowden N, D'Souza S, Gibb S, Milne B, Meehan L.   +5 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

New European Qualifications Framework for Engineering Education

Aplūkоtas Eiropas Vienotā tirgus aktivitātes un noskaidrota atbilstības novērtēšanas un tās sistēmu loma un nozīme Vienotā tirgū. Atsaucoties uz Jauno Lisabonas „Sadarbība izaugsmei un nodarbinātībai” dokumentu, kā arī ES „Jauno rūpniecības politiku ...
Mazais, Jānis, Janauska, Jolanta, Salenieks, Narimants   +2 more
core  

Nursing education in conflict: How intersectionality impacts access to educational opportunities? [PDF]

Front Med (Lausanne)
Hinsche L, Hasseler M, Tischendorf T, Schaal T.   +3 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Predicted positions and qualification mismatch for master of nursing graduates in Croatian hospitals: cross-sectional study. [PDF]

BMC Nurs
Vuksa A, Puljak L.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source