Results 61 to 70 of about 9,681,542 (365)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Measuring dispersion in the context of ordered qualitative scales [PDF]

, 2018
Producción CientíficaThe main purpose of this contribution is to measure the dispersion associated with the different results of a variable when they form a set of linguistic terms obtained after examining different qualities of people, services, etc ...
Borge González, Luis Moisés, García Lapresta, José Luis   +1 more
core   +1 more source

Qualitative Theory for Lensed QSOs

, 2003
We show that some characteristics of multiply-imaged QSO systems are very model-independent and can be deduced accurately by simply scrutinizing the relative positions of images and galaxy-lens center.
Claeskens J.-F., Liliya L. R. Williams, Prasenjit Saha, Saha P., Schneider P.   +4 more
core   +1 more source

Fuzzy qualitative simulation with multivariate constraints [PDF]

, 2014
Postprin
Coghill, George M, Pang, Wei
core   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Qualitative study in Loop Quantum Cosmology [PDF]

, 2016
This work contains a detailed qualitative analysis, in General Relativity and in Loop Quantum Cosmology, of the dynamics in the associated phase space of a scalar field minimally coupled with gravity, whose potential mimics the dynamics of a perfect ...
Llibert Aresté Saló, Jaume Amorós, Jaume de Haro, Fernández-Jambrina L, Barrow J D, Barrow J D, Nojiri S, Bamba K, Ashtekar A, Agullo I, Singh P, Sani S, Singh P, Heard I P C, Wilson-Ewing E, Wilson-Ewing E, Cai Y-F, Haro J, Haro J, Lehners J-L, Haro J, Bamba K, de Haro J, Meissner K A, Singh P, Haro J, de Haro J   +26 more
core   +14 more sources

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Psychological meanings reported by patients with Graves’ Disease in hyperthyroidism but without ophthalmopathy about their quotidian life: A qualitative study conducted in a Brazilian university specialized outpatient service

European Psychiatry
Introduction To handle well clinical treatments, it is crucial to know the expectations of patients who seek help. We need to ask ourselves: how do patients interpret subjectively their diagnosis, treatments, and self-care?
L. S. Valladão, F. S. Silva, C. F. Casagrande, L. M. Guerra, D. E. Zantut-Wittmann, E. R. Turato   +5 more
doaj   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Qualitative Analysis of Early Universe Cosmologies [PDF]

, 1999
A qualitative analysis is presented for a class of homogeneous cosmologies derived from the string effective action when a cosmological constant is present in the matter sector of the theory.
Billyard, Andrew P, Coley, Alan A, Lidsey, James E   +2 more
core   +2 more sources