Results 41 to 50 of about 1,137,388 (248)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Verbatim: Archiving Qualitative Data and Secondary Analysis in a French Company
Forum: Qualitative Social Research, 2000 Archiving qualitative data analysis and secondary analysis, first developed in the USA and in the Northern European countries, is not a current practice in France. To our knowledge, we are the first to have developed it in a French context.
Dominique Le Roux, Jean Vidal
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Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Conducting Qualitative Data Analysis: Qualitative Data Analysis as a Metaphoric Process
The Qualitative Report, 2015 In the second of a series of “how-to” essays on conducting qualitative data analysis, Ron Chenail argues the process can best be understood as a metaphoric process. From this orientation he suggests researchers follow Kenneth Burke’s notion of metaphor and see qualitative data analysis as the analyst systematically considering the “this-ness” of the ...
openaire +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Iterative Chat Transcript Analysis: Making Meaning from Existing Data
Evidence Based Library and Information Practice, 2016 Objective – In order to better contextualize library data about patron satisfaction with reference services, we analyzed an existing corpus of chat transcripts. Having conducted a similar analysis in 2010, we also compared librarian behaviors over time.
Steven Baumgart +2 more
doaj +3 more sources
Review: Graham Gibbs (2009). Analysing Qualitative Data
Forum: Qualitative Social Research, 2010 The reviewed book concentrates on the issue of qualitative data analysis. It primarily provides practical information for students and social researchers on how to deal with textual data starting with data preparation until writing the actual report. The
Ewa Krzaklewska
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