Results 71 to 80 of about 19,601,698 (304)

Applying the criteria of Ulrich and Brockbank for the assessment of the role of human resources as a strategic business partner in a mining company

SA Journal of Human Resource Management, 2009
The aim of this study was to apply the 14 criteria of Ulrich and Brockbank for the assessment of the movement of a human-resource function from its current development phase to a strategic business-partner role. A qualitative method, based on casing, was
Lize de Bruyn, Gert Roodt
doaj   +1 more source

A qualitative evaluation approach for energy system modelling frameworks

, 2018
BackgroundThe research field of energy system analysis is faced with the challenge of increasingly complex systems and their sustainable transition. The challenges are not only on a technical level but also connected to societal aspects.
F. Wiese, S. Hilpert, Cord Kaldemeyer, G. Pleßmann   +3 more
semanticscholar   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Qualitative evaluation of antimicrobial use with gyssens method in the internal medicine wards of Adam Malik General Hospital Medan

Antimicrobial Stewardship & Healthcare Epidemiology
Objective: Antimicrobial resistance will become one of the most lethal conditions, which will raise burdens in many sectors across the One Health spectrum.
Restuti Hidayani Saragih, Lenni Evalena Sihotang, Fandy Ong Jaya, Terang Meliala, Otneil Karnianta Keliat, Lily Sherly Hasugian, Mario Eka Paskah Sinullinga, Maulinda Putri, Junita Tarigan, Franciscus Ginting   +9 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

The perceived impact of family medicine leadership training on practice: A qualitative study

African Journal of Primary Health Care & Family Medicine
Background: Family physicians (FPs) play a crucial role in clinical governance within South Africa’s District Health System, necessitating strong leadership skills.
Samantha Dladla, Klaus B. von Pressentin, Tasleem Ras   +2 more
doaj   +1 more source

‘Tiny Iceland’ preparing for Ebola in a globalized world

Global Health Action, 2019
Background: The Ebola epidemic in West Africa caused global fear and stirred up worldwide preparedness activities in countries sharing borders with those affected, and in geographically far-away countries such as Iceland.
Geir Gunnlaugsson, Íris Eva Hauksdóttir, Ib Christian Bygbjerg, Britt Pinkowski Tersbøl   +3 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source