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On Quantitative Evaluations of Counterfactuals

CoRR, 2021
As counterfactual examples become increasingly popular for explaining decisions of deep learning models, it is essential to understand what properties quantitative evaluation metrics do capture and equally important what they do not capture. Currently, such understanding is lacking, potentially slowing down scientific progress.
Frederik Hvilshøj, Alexandros Iosifidis, Ira Assent   +2 more
openaire   +2 more sources

Patient-proxy agreement on change in acute stroke patient-reported outcome measures: a prospective study

Journal of Patient-Reported Outcomes, 2021
Objectives Research has indicated proxies overestimate symptoms on patients’ behalves, however it is unclear whether patients and proxies agree on meaningful change across domains over time.
Brittany R. Lapin, Nicolas R. Thompson, Andrew Schuster, Irene L. Katzan   +3 more
doaj   +1 more source

A Quantitative Evaluation of SAGE [PDF]

Genome Research, 2000
Serial Analysis of Gene Expression (SAGE) is an innovative technique that offers the potential of cataloging both the identity and relative frequencies of mRNA transcripts in a given poly(A+) RNA preparation. Although it is a very effective approach for determining the expression of mRNA populations, there are significant biases in the observed results
J, Stollberg, J, Urschitz, Z, Urban, C D, Boyd   +3 more
openaire   +2 more sources

Regulatory utility of mechanistic modeling to support alternative bioequivalence approaches: A workshop overview

CPT: Pharmacometrics & Systems Pharmacology, 2023
On September 30 and October 1, 2021, the US Food and Drug Administration (FDA) and the Center for Research on Complex Generics cosponsored a live virtual workshop titled “Regulatory Utility of Mechanistic Modeling to Support Alternative Bioequivalence ...
Andrew Babiskin, Fang Wu, Youssef Mousa, Ming‐Liang Tan, Eleftheria Tsakalozou, Ross L. Walenga, Miyoung Yoon, Sam G. Raney, James E. Polli, Anna Schwendeman, Vishalakshi Krishnan, Lanyan Fang, Liang Zhao   +12 more
doaj   +1 more source

Quantitative methods and modeling to assess COVID‐19‐interrupted in vivo pharmacokinetic bioequivalence studies with two reference batches

CPT: Pharmacometrics & Systems Pharmacology, 2022
The coronavirus disease 2019 (COVID‐19) has presented unprecedented challenges to the generic drug development, including interruptions in bioequivalence (BE) studies.
Yuqing Gong, Kairui Feng, Peijue Zhang, Jieon Lee, Yuzhuo Pan, Zhen Zhang, Zhanglin Ni, Tao Bai, Miyoung Yoon, Bing Li, Carol Y. Kim, Lanyan Fang, Liang Zhao   +12 more
doaj   +1 more source

Physiologically‐based pharmacokinetic modeling to support bioequivalence and approval of generic products: A case for diclofenac sodium topical gel, 1%

CPT: Pharmacometrics & Systems Pharmacology, 2021
Establishing bioequivalence (BE) for dermatological drug products by conducting comparative clinical end point studies can be costly and the studies may not be sufficiently sensitive to detect certain formulation differences.
Eleftheria Tsakalozou, Andrew Babiskin, Liang Zhao   +2 more
doaj   +1 more source

Evaluation of model‐based bioequivalence approach for single sample pharmacokinetic studies

CPT: Pharmacometrics & Systems Pharmacology, 2023
In a traditional pharmacokinetic (PK) bioequivalence (BE) study, a two‐way crossover study is conducted, PK parameters (namely the area under the time‐concentration curve [AUC] and the maximal concentration [Cmax]) are obtained by noncompartmental ...
Coralie Tardivon, Florence Loingeville, Mark Donnelly, Kairui Feng, Wanjie Sun, Guoying Sun, Stella Grosser, Liang Zhao, Lanyan Fang, France Mentré, Julie Bertrand   +10 more
doaj   +1 more source

Quantitative Evaluation of Drusen on Photographs [PDF]

Ophthalmology, 2013
Visualizing and tracking drusen is important in managing age-related macular degeneration (AMD). Color fundus photography (CFP) is common in clinical practice, and but quantitative evaluation of drusen in CFPs is difficult because of the varying background of macula, retinal pigment epithelium (RPE), and choroid.1 Spectral-domain optical coherence ...
Daniel L, Rubin, Luis, de Sisternes, Lauren, Kutzscher, Qiang, Chen, Theodore, Leng, Luo Luo, Zheng   +5 more
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Deletion statistic accuracy in confirmatory factor models

Methodological Innovations, 2020
Social science researchers now routinely use confirmatory factor models in scale development and validation studies. Methodologists have known for some time that the results of fitting a confirmatory factor model can be unduly influenced by one or a few ...
Jennifer Koran, Fathima Jaffari
doaj   +1 more source

Quantitative Evaluation of BFT Protocols [PDF]

2011 Eighth International Conference on Quantitative Evaluation of SysTems, 2011
Byzantine Fault Tolerant (BFT) protocols aim to improve the reliability of distributed systems. They enable systems to tolerate arbitrary failures in a bounded number of nodes. BFT protocols are usually proven correct for certain safety and liveness properties.
Raluca Halalai, Thomas A. Henzinger, Vasu Singh   +2 more
openaire   +1 more source