Results 41 to 50 of about 1,352,768 (318)

Adaptation and Psychometric Validation of the Spanish Version of Two Measures of Agentic Engagement

Behavioral Sciences
This study focuses on the adaptation and psychometric validation of the Spanish versions of the Agentic Engagement Scale (AES) and the Enlarged Version of the Agentic Engagement Scale (EVAES) in Spanish undergraduate students.
Estefania Guerrero, Georgina Guilera, Alba Aza, Juana Gómez-Benito, Maite Barrios   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Predictive Analysis for First Submission of Generic Drug Application for Orphan Drug Products Using Random Survival Forest

Clinical and Translational Science
Rare diseases affect a small population of patients, resulting in low incentives for developing orphan drug products (ODPs). The United States Congress passed the Orphan Drug Act of 1983 to incentivize pharmaceutical manufacturers to develop drugs to ...
Robert Hopefl, Jing Wang, Abhinav Ram Mohan, Wei‐Jhe Sun, Myong‐Jin Kim, Meng Hu, Lanyan Fang   +6 more
doaj   +1 more source

Enhancing patient-reported outcomes in stroke care: a path to improved well-being

Frontiers in Neurology
Patient-reported outcomes (PROs) present a valuable opportunity to enhance stroke care by capturing symptoms and experiences often missed by traditional outcome measures like the modified Rankin Scale.
Irene L. Katzan, Irene L. Katzan, Nicolas R. Thompson, Nicolas R. Thompson, Ken Uchino, Ken Uchino, Brittany Lapin, Brittany Lapin   +7 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Quantitative Evaluation of Workspace Collaboration

2006 10th International Conference on Computer Supported Cooperative Work in Design, 2006
In this paper we propose an analytical approach based on models of human performance to evaluate workspace collaboration. Our results indicate that the approach: 1) facilitates the fine-grained analysis of workspace collaboration; 2) provides quantitative estimates of collaborative actions executed in shared workspaces; and 3) affords comparing ...
Antonio Ferreira 0001, Pedro Antunes 0001   +1 more
openaire   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Quantitative Evaluation of Defects by Fuzzy Reasoning Based on Principal Component Analysis

, 1996
Ultrasonic waveforms reflected by various kinds of defects were calculated by numerical analysis based on elastic wave theory. By using these calculated results as a knowledge base, development of nondestructive evaluation system which provides ...
Y. Yabe, Kitahara, M., T. Ogi, Ogi, T., Achenbach, J., Mandai, T., Yabe, Y., M. Kitahara, T. Mandai, J. D. Achenbach   +9 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Quantitative Nondestructive Evaluation Techniques for Investigation of Very Thin Coatings

, 1999
Coatings are widely used in industry. They provide good electrical conductivity, wear resistance, thermal and electrical insulation, and corrosion protection.
Maev, R., R. Gr. Maev, de Halleux, B., A. Ptchelintsev, Titov, S., S. Titov, Ptchelintsev, A., B. de Halleux   +7 more
core   +1 more source