Results 61 to 70 of about 3,919,708 (282)

Two Approaches to Dislocation Nucleation in the Supported Heteroepitaxial Equilibrium Islanding Phenomenon

, 2008
We study the dislocation formation in 2D nanoscopic islands with two methods, the Molecular Static method and the Phase Field Crystal method. It is found that both methods indicate the same qualitative stages of the nucleation process.
E Granato, J Jalkanen, Jònsson H, K Elder, Moll M, O Trushin, S C Ying, T Ala-Nissilä, Trushin O, Wang L G   +9 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

High-contrast dark resonance on the D2 - line of 87Rb in a vapor cell with different directions of the pump - probe waves

, 2005
We propose a novel method enabling to create a high-contrast dark resonance in the 87Rb vapor D2-line. The method is based on an optical pumping of atoms into the working states by a two-frequency, linearly-polarized laser radiation propagating ...
1, 20, 36, 49, 65, 80, Agap’ev, B. Matisov, Bhaskar, Deng, G. Kazakov, G. Mileti, Gornyi, I. Mazets, J. Delporte, Yu. Rozhdestvensky   +15 more
core   +1 more source

Qualitative theory testing as mixed-method research [PDF]

, 2006
While the concept of mixed-methods research is more usually associated with combining quantitative and qualitative approaches, this paper outlines a study that mixed methods by undertaking qualitative theory testing and derivation when examining the ...
Abercrombie, N., Adam, E., Beattie, A., Burrell, G., Campbell, T., Crotty, M., Cuff, E.C., Ellis, R., Fawcett, J., Fawcett, J., Feyerabend, P., Guba, E.G., Harralambos, M., Jary, D., Kerlinger, F.N., Laudan, L., Layder, D., Leddy, S., Marriner-Tomey, A., Meleis, A.I., Miller, S., Naidoo, J., Polit, D.F., Polit, D.F., Popper, K.R., Rawson, D., Rawson, D., Schutz, A., Stewart Piper, Suppe, F., Tones, K., Turner, J.M., Walker, L.O., Watson, J., Weber, M.   +34 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Digital Network as a Learning Tool for Health Sciences Students

Seminar.net, 2012
An online learning module for health sciences students with various educational backgrounds was implemented at the University of Tromsø (UiT). The purpose of this article is to examine how participation in a joint, web-based course can be a didactic tool
Ragnhild Nilsen
doaj  

Introduction to Research Methodology: Standard Procedures for Qualitative Data Analysis [PDF]

سیاست نامه علم و فناوری, 2019
The emergence and development of qualitative methodology over the past few years in the social and human sciences community of Iran has been the subject of controversy in theory and practice in a number of ways. The increasing attention to and increasing
Amirhossein Tayebi Abolhasani
doaj  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source