Results 31 to 40 of about 1,720,879 (293)

Pathways and identity: toward qualitative research careers in child and adolescent psychiatry

Child and Adolescent Psychiatry and Mental Health
Objective Qualitative research methods are based on the analysis of words rather than numbers; they encourage self-reflection on the investigator’s part; they are attuned to social interaction and nuance; and they incorporate their subjects’ thoughts and
Andrés Martin, Madeline DiGiovanni, Amber Acquaye, Matthew Ponticiello, Débora Tseng Chou, Emilio Abelama Neto, Alexandre Michel, Jordan Sibeoni, Marie-Aude Piot, Michel Spodenkiewicz, Laelia Benoit   +10 more
doaj   +1 more source

The experience of conducting collaborative and intensive pragmatic qualitative (CLIP-Q) research to support rapid public health and healthcare innovation

Frontiers in Sociology, 2022
A key challenge for qualitative methods in applied health research is the fast pace that can characterize the public health and health and care service landscape, where there is a need for research informed by immediate pragmatic questions and relevant ...
Jeremy Horwood, Jeremy Horwood, Jeremy Horwood, Christalla Pithara, Christalla Pithara, Ava Lorenc, Joanna M. Kesten, Joanna M. Kesten, Joanna M. Kesten, Mairead Murphy, Mairead Murphy, Andrew Turner, Andrew Turner, Michelle Farr, Michelle Farr, Jon Banks, Jon Banks, Sabi Redwood, Sabi Redwood, Helen Lambert, Helen Lambert, Helen Lambert, Jenny L. Donovan, Jenny L. Donovan, NIHR ARC West Behavioural and Qualitative Science Team, NIHR ARC West Behavioural and Qualitative Science Team   +25 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

A method for measuring detailed demand for workers’ competences

Economics: Journal Articles, 2019
There is an increasing need for analysing the demand for skills in the labour market. While most studies aggregate skills in groups or use available proxies for them, the authors analyse the demand by employers for individual competences.
Pater Robert, Szkola Jaroslaw, Kozak Marcin   +2 more
doaj   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Inequalities in accessing public transportation and social exclusion among older adults and people with disabilities in Bangladesh: A scoping review

Transportation Research Interdisciplinary Perspectives
In the rapidly evolving landscape of urbanisation and transportation infrastructure in Bangladesh, it is critical to address the disparities in public transportation access that disproportionately affect vulnerable people such as older adults and people ...
Selim Jahangir, Ajay Bailey, Md Musleh Uddin Hasan, Shanawez Hossain   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source