Results 41 to 50 of about 15,907,715 (276)

The experience of conducting collaborative and intensive pragmatic qualitative (CLIP-Q) research to support rapid public health and healthcare innovation

Frontiers in Sociology, 2022
A key challenge for qualitative methods in applied health research is the fast pace that can characterize the public health and health and care service landscape, where there is a need for research informed by immediate pragmatic questions and relevant ...
Jeremy Horwood, Jeremy Horwood, Jeremy Horwood, Christalla Pithara, Christalla Pithara, Ava Lorenc, Joanna M. Kesten, Joanna M. Kesten, Joanna M. Kesten, Mairead Murphy, Mairead Murphy, Andrew Turner, Andrew Turner, Michelle Farr, Michelle Farr, Jon Banks, Jon Banks, Sabi Redwood, Sabi Redwood, Helen Lambert, Helen Lambert, Helen Lambert, Jenny L. Donovan, Jenny L. Donovan, NIHR ARC West Behavioural and Qualitative Science Team, NIHR ARC West Behavioural and Qualitative Science Team   +25 more
doaj   +1 more source

“We Cannot Talk as a Family”: Complexities of Survivorship Communication Among Hispanic/Latino Young Adult Survivors of Childhood Cancer, Parents, and Clinicians

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Young adult childhood cancer survivors (YA‐CCS) have an increased risk of treatment‐related health complications throughout their lives. Lifelong survivorship care is recommended, yet many YA‐CCS experience disruptions in care during pediatric‐to‐adult transitions and do not receive recommended survivorship care.
Kevin Shanchen Pu, Nicole Fernández‐Viña, Briana C. Martin‐Villa, Daniela Ramirez, Rebecca M. Lewinsohn, Mary Smith, Heidi Boynton, Lidia Schapira, Stephanie M. Smith   +8 more
wiley   +1 more source

Pathways and identity: toward qualitative research careers in child and adolescent psychiatry

Child and Adolescent Psychiatry and Mental Health
Objective Qualitative research methods are based on the analysis of words rather than numbers; they encourage self-reflection on the investigator’s part; they are attuned to social interaction and nuance; and they incorporate their subjects’ thoughts and
Andrés Martin, Madeline DiGiovanni, Amber Acquaye, Matthew Ponticiello, Débora Tseng Chou, Emilio Abelama Neto, Alexandre Michel, Jordan Sibeoni, Marie-Aude Piot, Michel Spodenkiewicz, Laelia Benoit   +10 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A method for measuring detailed demand for workers’ competences

Economics: Journal Articles, 2019
There is an increasing need for analysing the demand for skills in the labour market. While most studies aggregate skills in groups or use available proxies for them, the authors analyse the demand by employers for individual competences.
Pater Robert, Szkola Jaroslaw, Kozak Marcin   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Inequalities in accessing public transportation and social exclusion among older adults and people with disabilities in Bangladesh: A scoping review

Transportation Research Interdisciplinary Perspectives
In the rapidly evolving landscape of urbanisation and transportation infrastructure in Bangladesh, it is critical to address the disparities in public transportation access that disproportionately affect vulnerable people such as older adults and people ...
Selim Jahangir, Ajay Bailey, Md Musleh Uddin Hasan, Shanawez Hossain   +3 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source