Results 121 to 130 of about 21,139,354 (341)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

The projected changes in quality adjusted life years lost related to COPD in Canada in men (A) and women (B).

, 2012
The projected changes in quality adjusted life years lost related to COPD in Canada in men (A) and women (B).
Larry D. Lynd (115952), Mehdi Najafzadeh (128547), Mohsen Sadatsafavi (63962), J. Mark FitzGerald (115951), Bruce McManus (128550), Don Sin (128552), Carlo A. Marra (115949)   +6 more
core   +1 more source

Medical costs and quality-adjusted life years associated with smoking: a systematic review

BMC Public Health, 2016
Background Estimated medical costs (“T”) and QALYs (“Q”) associated with smoking are frequently used in cost-utility analyses of tobacco control interventions.
Shari P. Feirman, Allison M. Glasser, Lyubov Teplitskaya, David R. Holtgrave, David B. Abrams, Raymond S. Niaura, Andrea C. Villanti   +6 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Cost-utility model input parameters: Principal event probabilities, lifetime costs and quality-adjusted life years.

Cost-utility model input parameters: Principal event probabilities, lifetime costs and quality-adjusted life years.
Dyfrig Hughes (40543), Bernd Duller (3834748), Elke Naujokat (18358266), Huw Lloyd Williams (18495674), Emily Holmes (418302), Christian P. Subbe (18495677)   +5 more
core   +1 more source

Cost-utility tele-stroke in adults with acute ischemic stroke. A systematic review

Public Health in Practice
Introduction: Tele-Stroke has been proposed as a solution to increase access to thrombolytic therapy in acute ischemic stroke. Objective: Synthesise the evidence of the cost-effectiveness of Tele-Stroke.
Luis Alberto López-Romero, Dora Inés Parra, Alexandra Cortés Aguilar, Fabio Alberto Camargo Figuera   +3 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

A Good Life in Later Years: A Co-Produced Research Project [PDF]

, 2017
The ‘A Good Life Project’ evolved as a co-production study looking at quality of life in later years. Funded by the Life Changes Trust, and in partnership with Age Scotland, researchers from the University of Stirling worked hand in hand with
Gibson, Grant, Robertson, Jane, Greasley-Adams, Corinne, McCall, Vikki   +3 more
core  

Trial‐based economic evaluation of mindfulness‐based cognitive therapy compared to treatment as usual for bipolar disorder

International Journal of Methods in Psychiatric Research
Objective Aim of this study was to assess the cost‐effectiveness and cost‐utility of mindfulness‐based cognitive therapy (MBCT) and treatment as usual (TAU) compared to TAU alone in adults with Bipolar disorder (BD). Methods An economic evaluation with a
Ben Wijnen, Maud Jansen, Annelieke vanVelthoven, Imke Hanssen, Marloes Huijbers, Silvia Evers, Anne Speckens   +6 more
doaj   +1 more source

Cost–utility analysis of adapted problem adaptation therapy for depression in mild-to-moderate dementia caused by Alzheimer's disease: PATHFINDER randomised controlled trial

BJPsych Open
Background Depression is common in people with dementia, and negatively affects quality of life. Aims This paper aims to evaluate the cost-effectiveness of an intervention for depression in mild and moderate dementia caused by Alzheimer's disease over ...
Monica Panca, Robert Howard, Elizabeth Cort, Charlotte Rawlinson, Rebecca L. Gould, Martin Wiegand, Anne Marie Downey, Sube Banerjee, Chris Fox, Rowan Harwood, Gill Livingston, Esme Moniz-Cook, Gregor Russell, Alan Thomas, Philip Wilkinson, Nick Freemantle, Rachael Maree Hunter   +16 more
doaj   +1 more source