Results 51 to 60 of about 1,591,231 (284)

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda   +15 more
wiley   +1 more source

Utility Weights for Allergic Rhinitis Based on a Community Survey with a Time Trade-off Technique in Japan

open access: yesAllergology International, 2009
Background: Allergic rhinitis is not a fatal disease, but its symptoms deteriorate the quality of life. High morbidity raises a concern about its impact on health care resources.
Kazuhiro Tamayama   +3 more
doaj   +1 more source

QALY: Quality Adjusted Life Year

open access: yesMedicine Science | International Medical Journal, 2012
Nufusun yaslanmasi ve yaslilik donemi hastaliklar ile kronik hastaliklarin one cikmasi verilen saglik hizmetlerinin sadece saglik duzeyi uzerine degil yasam kalitesine etkisinin de onemli bir cikti olarak degerlendirilmesini getirmistir. Aslinda bu yaklasim Dunya Saglik Orgutunun (WHO), 1946 yilinda sagligi “yalnizca hastalik ve sakatligin ...
Selale Sahin, Selime Toprak, Erdinc Unal
openaire   +2 more sources

Estimation of Quality‐adjusted Life Years alongside clinical trials: the impact of ‘time‐effects’ on trial results

open access: yesJournal of Pharmaceutical Health Services Research, 2018
The objectives were to investigate the impact of ‘time‐effect’ on the estimation of quality‐adjusted life years (QALYs) along prospective clinical trials’ outcomes using an assumed fixed time duration versus the actual time durations for each case.
Morro M L Touray
semanticscholar   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

A narrative review on the burden of migraine: when the burden is the impact on people’s life

open access: yesThe Journal of Headache and Pain, 2019
Background The burden of headache disorders, and of migraine in particular, is multifaceted and fragmented. The aim of this narrative review is to provide a description the main topics underlying the concepts of burden and impact of migraine disorders ...
Matilde Leonardi, Alberto Raggi
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

Commentary on the Urgent Need for Comprehensive Cost-Effectiveness Studies in Temporomandibular Disorders

open access: yesJournal of the California Dental Association
Objective This commentary underscores the critical need for focused, comprehensive research on the cost-effectiveness of treatments for temporomandibular disorders (TMD). While some studies have explored this area, a notable gap in systematic evaluations
K. Davina Frick, Anisha Paul-Ledesma
doaj   +1 more source

Economic burden on stroke survivors in Asian and African countries: A protocol for systematic review, meta-analysis, and meta-regression

open access: yesInternational Journal of Noncommunicable Diseases, 2023
Introduction: Stroke is one of the leading causes of morbidity and mortality worldwide accompanied by huge financial burden on an individual and society.
Summaiya Zareen Shaikh   +3 more
doaj   +1 more source

Valuing the benefit of varicella vaccination: comparison of willingness to pay and quality-adjusted life-years [PDF]

open access: yes, 2004
Vaccination is different from most health interventions because it is preventative, it protects against infectious disease (leading to knock-on effects), the diseases it prevents are usually acute and self-limiting, and most vaccines are given to ...
Brisson, M., Edmunds, J.
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