Fundamental Measurement and Quality-Adjusted Life Years [PDF]
Paul C Langley, Stephen P. McKenna
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Cost-Benefit Estimation of Cadaveric Kidney Transplantation, the Case of a Developing Country [PDF]
In this paper we estimate cost savings for the health-care system and quality of life improvement for patients from an increase in the number of kidney transplants in Chile. To do so, we compare the present value of dialysis and transplantation costs and
Javier Dominguez, Rodrigo Harrison
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Preoperative falls predict postoperative falls, functional decline, and surgical complications [PDF]
BackgroundFalls are common and linked to morbidity. Our objectives were to characterize postoperative falls, and determine whether preoperative falls independently predicted postoperative falls (primary outcome), functional dependence, quality of life ...
Abdallah, Arbi Ben+8 more
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Effective diabetes complication management is a step toward a carbon-efficient planet: an economic modeling study [PDF]
Background The management of diabetes-related complications accounts for a large share of total carbon dioxide equivalent (CO2e) emissions. We assessed whether improving diabetes control in people with type 2 diabetes reduces CO2e emissions, compared ...
Chatterjee, Mou+8 more
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KIF5A p.Pro986Leu Risk Variant and Accelerated Progression of Amyotrophic Lateral Sclerosis
ABSTRACT This study explored the impact of KIF5A rs113247976 (p.Pro986Leu), a risk allele for amyotrophic lateral sclerosis (ALS), on phenotypic variability in two Italian ALS cohorts (discovery, n = 865; replication, n = 1174). The minor allele (T) frequency was 0.015.
Arianna Manini+24 more
wiley +1 more source
Highlights: 1. This study emphasizes the importance of providing physical exercises to pre-frail elderly individuals, especially in a community setting. 2.
Sri Soenarti+4 more
doaj +1 more source
Cost-Effectiveness of Vaccination versus Treatment of Influenza in Healthy Adolescents and Adults [PDF]
At present time, there is uncertainty regarding whether influenza-like illness in healthy adults is best managed by preventive efforts that use the trivalent influenza vaccine, administration of neuraminidase inhibitors at the onset of illness, or ...
Khan, Kamran, Muennig, Peter A.
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Glycosylation Gene Signatures as Prognostic Biomarkers in Glioblastoma
ABSTRACT Objective Glioblastoma (GBM) is an aggressive brain tumor characterized by significant heterogeneity. This study investigates the role of glycosylation‐related genes in GBM subtyping, prognosis, and response to therapy. Methods We analyzed mRNA expression data and clinical information from The Cancer Genome Atlas (TCGA) and Gene Expression ...
Tong Zhao+4 more
wiley +1 more source
Problems and solutions in calculating quality-adjusted life years (QALYs).
The quality-adjusted life-year (QALY) is a measure of the value of health outcomes. Since health is a function of length of life and quality of life, the QALY was developed as an attempt to combine the value of these attributes into a single index number. The QALY calculation is simple: the change in utility value induced by the treatment is multiplied
José A. Sacristán, Luis Prieto
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Cost-effectiveness of lung transplantation in The Netherlands: a scenario analysis [PDF]
STUDY OBJECTIVES: To calculate cost-effectiveness of scenarios concerning lung transplantation in The Netherlands. DESIGN: Microsimulation model predicting survival, quality of life, and costs with and without transplantation program, based on data of
Al, M.J. (Maiwenn)+6 more
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