Results 81 to 90 of about 1,413,386 (299)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Rehabilitation Impact of Vivifrail Exercise Program Type C on the Cognitive Function of Pre-Frail Elderly People in the Community

open access: yesFolia Medica Indonesiana
Highlights: 1. This study emphasizes the importance of providing physical exercises to pre-frail elderly individuals, especially in a community setting. 2.
Sri Soenarti   +4 more
doaj   +1 more source

Cost-Benefit Estimation of Cadaveric Kidney Transplantation, the Case of a Developing Country [PDF]

open access: yes
In this paper we estimate cost savings for the health-care system and quality of life improvement for patients from an increase in the number of kidney transplants in Chile. To do so, we compare the present value of dialysis and transplantation costs and
Javier Dominguez, Rodrigo Harrison
core  

Forecasting the Effects of Obesity and Smoking on U.S. Life Expectancy [PDF]

open access: yes, 2011
Background: While increases in obesity over the past 30 years have adversely affected population health, there have been concomitant improvements due to reductions in smoking.
Cutler, David M.   +2 more
core   +2 more sources

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

open access: yesAging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss   +12 more
wiley   +1 more source

Global economic differences in modern glioblastoma care – a systematic review

open access: yesActa Neurochirurgica
Purpose Glioblastoma (GBM) is the most aggressive form of primary brain cancer and is associated with poor overall survival and expensive, resource intensive treatments.
Reuben Christopher   +5 more
doaj   +1 more source

Methods for the estimation of the National Institute for Health and Care Excellence cost-effectiveness threshold

open access: yesHealth Technology Assessment, 2015
Background: Cost-effectiveness analysis involves the comparison of the incremental cost-effectiveness ratio of a new technology, which is more costly than existing alternatives, with the cost-effectiveness threshold.
Karl Claxton   +8 more
doaj   +1 more source

Productivity and quality-adjusted life years: QALYs, PALYs and beyond

open access: yes, 2023
We develop a unified framework for the measurement and valuation of health and productivity. Within this framework, we characterize evaluation functions allowing for compromises between the classical quality-adjusted life years (QALYs) and its polar productivity-adjusted life years (PALYs).
Schultz Hansen, Kristian   +2 more
openaire   +3 more sources

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham   +7 more
wiley   +1 more source

Health-related quality of life in patients with colorectal neoplasm and cost-effectiveness of colorectal cancer screening in Hong Kong [PDF]

open access: yes, 2015
Key Messages 1. Compared with the Hong Kong general population norm, Chinese patients with colorectal neoplasm (CRN) reported worse physical health-related quality of life (HRQOL) but better mental HRQOL and comparable health preference scores. 2. The
Chan, P   +6 more
core  

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