Results 61 to 70 of about 1,413,386 (299)

Long-term cost-effectiveness of ticagrelor versus clopidogrel in acute coronary syndrome in Spain [PDF]

Farmacia Hospitalaria, 2014
Objective: To assess the cost-effectiveness relationship of Ticagrelor versus Clopidogrel for the management of acute coronary syndrome in Spain. Methods: The data from the PLATO study were used for the calculation of the events rate and health-related
E. Molina-Cuadrado, H. Mateo-Carrasco, P. Nieto-Guindo, P. Rodríguez-Gómez   +3 more
doaj   +1 more source

Association Between Sedentary Time and Quality of Life From the Osteoarthritis Initiative: Who Might Benefit Most From Treatment? [PDF]

, 2017
Objective To investigate the relationship between sedentary behavior and quality-adjusted life years (QALYs) among participants in the Osteoarthritis Initiative. Design Longitudinal, observational design.
Chang, Rowland W., Dunlop, Dorothy D., Ehrlich-Jones, Linda S., Lee, Jungwha, Pellegrini, Christine A., Pinto, Daniel, Semanik, Pamela A., Song, Jing   +7 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Cost-utility of transcatheter aortic valve implantation for inoperable patients with severe aortic stenosis treated by medical management: a UK cost-utility analysis based on patient-level data from the ADVANCE study. [PDF]

, 2014
OBJECTIVE: To use patient-level data from the ADVANCE study to evaluate the cost-effectiveness of transcatheter aortic valve implantation (TAVI) compared to medical management (MM) in patients with severe aortic stenosis from the perspective of the UK ...
Bleiziffer, S, Bosmans, J, Brecker, S, Busca, R, Eaton, J, Gerckens, UJ, Linke, A, Mealing, S, Moat, N, Padhiar, A, Piazza, N, Sculpher, M, Tamburino, C, Wenaweser, P   +13 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Cost-effectiveness of proton beam therapy for intraocular melanoma. [PDF]

PLoS ONE, 2015
Proton beam therapy is a commonly accepted treatment for intraocular melanomas, but the literature is lacking in descriptions of patient preferences of clinical outcomes and economic impact.
James P Moriarty, Bijan J Borah, Robert L Foote, Jose S Pulido, Nilay D Shah   +4 more
doaj   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Economic evaluations of 13-valent pneumococcal conjugate vaccine: a systematic review

Expert Review of Vaccines, 2023
Introduction Studies on economic evaluations of the 13-valent pneumococcal conjugate vaccine (PCV13) have been increasing over the last decade. No systematic reviews have synthesized the evidence of economic evaluations of the PCV13.
Yuanze Du, Yi Wang, Ting Zhang, Juanjuan Li, Hewei Song, Yuanyuan Wang, Yifei Xu, Jingwen Cui, Ming Yang, Zengwu Wang, Xiuyun Wu, Chunping Wang   +11 more
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Therapies for Advanced Parkinson’s Disease in Sweden: A Cost-Effectiveness Analysis Using Real-World Data

Neurology and Therapy
Introduction The Swedish Parkinson’s Disease (PD) Registry provides rich data on cost and quality of life for patients receiving device-aided therapies (DATs) for Parkinson’s disease in Sweden.
Dag Nyholm, Simon Eggington, Astrid Holm
doaj   +1 more source