Results 71 to 80 of about 1,397,662 (274)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A Patch-Level Region-Aware Module with a Multi-Label Framework for Remote Sensing Image Captioning

Remote Sensing
Recent Transformer-based works can generate high-quality captions for remote sensing images (RSIs). However, these methods generally feed global or grid visual features to a Transformer-based captioning model for associating cross-modal information ...
Yunpeng Li, Xiangrong Zhang, Tianyang Zhang, Guanchun Wang, Xinlin Wang, Shuo Li   +5 more
doaj   +1 more source

Multiscale attention dynamic aware network for fine‐grained visual categorization

Electronics Letters, 2023
Fine‐grained visual categorization (FGVC) is a challenging task, facing the issues such as inter‐class similarities, large intra‐class variances, scale variation, and angle variation.
Jichu Ou, Wanyi Li, Jingmin Huang, Xiaojie Huang, Xuan Xie   +4 more
doaj   +1 more source

Deep Cropping via Attention Box Prediction and Aesthetics Assessment

, 2017
We model the photo cropping problem as a cascade of attention box regression and aesthetic quality classification, based on deep learning. A neural network is designed that has two branches for predicting attention bounding box and analyzing aesthetics ...
Shen, Jianbing, Wang, Wenguan
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Toward accurate single image sand dust removal by utilizing uncertainty-aware neural network

Frontiers in Neurorobotics
Although deep learning methods have made significant strides in single image sand dust removal, the heterogeneous uncertainty induced by dusty environments poses a considerable challenge.
Bingcai Wei, Hui Liu, Chuang Qian, Haoliang Shen, Yibiao Chen, Yixin Wang   +5 more
doaj   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

OASL: Orientation-aware adaptive sampling learning for arbitrary oriented object detection

International Journal of Applied Earth Observations and Geoinformation
Arbitrary oriented object detection (AOOD) is a fundamental task in aeiral image interpretation, which is commonly implemented by optimizing three subtasks: classification, localization, and orientation.
Zifei Zhao, Shengyang Li
doaj   +1 more source