Results 71 to 80 of about 18,119,282 (331)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Combination method to estimate willingness to pay per quality-adjusted life year.

Combination method to estimate willingness to pay per quality-adjusted life year.
Klas Göran Sahlen (17935584), Lars Lindholm (21685), Anh Nu Vu (17935581), Minh Van Hoang (6842081), Cuc Thi Thu Nguyen (14059662), Sun Sun (15469762)   +5 more
core   +1 more source

Exempt_Consent_copy_ – Supplemental material for Quality-adjusted life year weights and treatment bias: Theory and evidence from cognitive interviews

, 2019
Supplemental material, Exempt_Consent_copy_ for Quality-adjusted life year weights and treatment bias: Theory and evidence from cognitive interviews by Bryan N Patenaude and Till Bärnighausen in SAGE Open ...
Bryan N Patenaude (6835328), Till Bärnighausen (36281)   +1 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Long-term cost-effectiveness of ticagrelor versus clopidogrel in acute coronary syndrome in Spain [PDF]

Farmacia Hospitalaria, 2014
Objective: To assess the cost-effectiveness relationship of Ticagrelor versus Clopidogrel for the management of acute coronary syndrome in Spain. Methods: The data from the PLATO study were used for the calculation of the events rate and health-related
E. Molina-Cuadrado, H. Mateo-Carrasco, P. Nieto-Guindo, P. Rodríguez-Gómez   +3 more
doaj   +1 more source

Overview of the methods for eliciting willingness to pay per quality-adjusted life year.

Overview of the methods for eliciting willingness to pay per quality-adjusted life year.
Klas Göran Sahlen (17935584), Lars Lindholm (21685), Anh Nu Vu (17935581), Minh Van Hoang (6842081), Cuc Thi Thu Nguyen (14059662), Sun Sun (15469762)   +5 more
core   +1 more source

Additional file 3: of Stillbirths: how should its rate be reported, its disability-adjusted-life-years (DALY), and stillbirths adjusted life expectancy

, 2019
Life expectancy & stillbirths adjusted life expectancy, 2000 & 2015, and i) decrease in life expectancy due to stillbirths, and ii) DALY = YLL of stillbirths, 2015, by country; format.
Chander Kant (6955988)
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Changes in life-space mobility and quality of life among community-dwelling older people: a 2-year follow-up study. [Elektronisk resurs]

, 2016
Life-space mobility refers to the spatial area in which a person moves in daily life, taking into account distance, frequency and assistance needed. The aim was to examine how changes in life-space mobility are associated with changes in quality of life (
Rantakokko, Merja,, Viljanen, Anne,, Rantanen, Taina,, Portegijs, Erja,, Kauppinen, Markku,, Iwarsson, Susanne,, Lund University.   +6 more
core   +1 more source