Results 201 to 210 of about 594,902 (254)

Stem Cell Transplantation in Friedreich Ataxia: Cure for Leukemia but No Effect on Neurological Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Friedreich Ataxia (FRDA) is a neurodegenerative disorder of children and young adults associated with cardiomyopathy and other systemic complications. We report a 10‐year‐old girl who presented simultaneously with Acute Myelogenous Leukemia and FRDA who was successfully treated for her leukemia with allogeneic hematopoietic stem cell ...
Alexandra Gitman, Niyati Bhandari, Maria Castellaro, Kim Schadt, María Cancio, David R. Lynch   +5 more
wiley   +1 more source

Integrating Time‐Adjusted Imaging Instability Into Functional Outcome Prediction After Intracerebral Hemorrhage: Development and Validation of the HAGIV Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early risk stratification may support clinical decision‐making in spontaneous intracerebral hemorrhage (ICH). We aimed to develop and internally validate HAGIV, a score integrating frequency of imaging markers (FIM), a time‐adjusted non‐contrast computed tomography (CT) metric of hematoma expansion, with established predictors for 90‐
Lei Song, Ren Ke, Anqi Chen, Yufei Fu, Hang Zhou, Rujia Wang, Liwei Zou, Yongqiang Yu, Ming Yuan, Xiaoming Qiu, Mengzhou Xue   +10 more
wiley   +1 more source

The Multiple Sclerosis Severity Allele rs10191329A and Cognitive Function: A UK Biobank Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The genome‐wide association study of Multiple Sclerosis severity linked the genetic variant rs10191329A to long‐term disability and implicated brain resilience as a determinant of outcome. We hypothesised that rs10191329A might influence cognition in other neurological diseases and healthy controls.
Ioanna Zimianiti, Sheena Waters, Adil Harroud, Pernilla Stridh, Ruth Dobson, Benjamin M. Jacobs   +5 more
wiley   +1 more source

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Not all “quality-adjusted life years” are equal

Journal of Clinical Epidemiology, 2007
There is evidence that utility elicitation methods used in the calculation of quality-adjusted life years (QALYs) yield different results. It is not clear how these differences impact economic evaluations.Using a mathematical model incorporating data on efficacy, costs, and utility values, we simulated the experiences of 100,000 hypothetical rheumatoid
C A, Marra, S A, Marion, D P, Guh, M, Najafzadeh, F, Wolfe, J M, Esdaile, A E, Clarke, M A, Gignac, A H, Anis   +8 more
openaire   +4 more sources

Quality-Adjusted Life Years

Practical Neurology, 2008
Many health systems now use cost-effectiveness analysis to decide which interventions and programmes to fund. A key issue for such decision making is how to measure health outcomes from interventions to reflect changes in both health-related quality of life and life expectancy.
Yolanda, Bravo Vergel, Mark, Sculpher
openaire   +3 more sources

Utilities and Quality-Adjusted Life Years

International Journal of Technology Assessment in Health Care, 1989
Utilities and quality-adjusted life years (QALYs) are reviewed, with particular focus on their use in technology assessment. This article provides a broad overview and perspective on these two techniques and their interrelationship, with reference to other sources for details of implementation.
G W, Torrance, D, Feeny
openaire   +2 more sources

Methods for quality adjustment of life years

Social Science & Medicine, 1992
Several valuation techniques are in use for quality adjusting life years in cost utility analysis. The paper gives an overview of the variability in results. A close inspection of a number of instruments with respect to their theme, instructions, decision framing and the phrasing of questions make many of the observed differences in results ...
openaire   +2 more sources

Quality-adjusted life years

Abstract The concept of quality-adjusted life years (QALY) is explained, with the approaches to measuring and problems with QALYs highlighted.
Phil Ambery, Adrian Kilcoyne, Daniel O’Connor   +2 more
  +4 more sources

The importance of Perspective in the Measurement of Quality-adjusted Life Years

Medical Decision Making, 1997
Scaling instruments for the measurement of quality-adjusted life years (QALYs) incor porate either a personal or an impersonal perspective on the benefits of a health intervention and either do or do not incorporate considerations of equity. This paper sets out three hypotheses concerning perspective and equity: 1) that more equally distributed ...
J, Richardson, E, Nord
openaire   +2 more sources

QUALITY-ADJUSTED LIFE-YEARS

The Lancet, 1987
Alan Williams, RogerW Evans, MichaelF Drummond   +2 more
  +6 more sources