Results 51 to 60 of about 19,026,882 (238)

The impact of childhood RSV infection on children's and parents' quality of life: a prospective multicenter study in Spain

BMC Infectious Diseases, 2021
Background  Several immunisation candidates against RSV are in late-stage clinical trials. To evaluate the benefits of a potential vaccination programme, both economic and health benefits will be needed.
Eva Díez-Gandía, Carla Gómez-Álvarez, Mónica López-Lacort, Cintia Muñoz-Quiles, Isabel Úbeda-Sansano, Javier Díez-Domingo, Alejandro Orrico-Sánchez, Study collaborators   +7 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Impact of Inactivated Influenza Vaccination on Health‐Related Quality of Life Among Japanese Healthcare Workers

Immunity, Inflammation and Disease
Background Influenza vaccinations are recommended for healthcare workers (HCWs). Quantification of the personal risks of vaccination compared to vaccine benefits can help guide more accurate benefit‐risk assessment and cost‐effectiveness analysis of ...
Taito Kitano, Sayaka Yoshida
doaj   +1 more source

Productivity and quality-adjusted life years: QALYs, PALYs and beyond

, 2023
We develop a unified framework for the measurement and valuation of health and productivity. Within this framework, we characterize evaluation functions allowing for compromises between the classical quality-adjusted life years (QALYs) and its polar productivity-adjusted life years (PALYs).
Schultz Hansen, Kristian, Moreno-Ternero, Juan D., Østerdal, Lars Peter   +2 more
openaire   +3 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Cost-Utility Analysis of Colorectal Cancer Screening Starting at Age 45 Compared to Age 50 in Colombia

Revista Colombiana de Gastroenterología
Background: Colorectal cancer (CRC) is among the four cancers with the highest incidence and mortality in Colombia. CRC screening is currently recommended in national guidelines starting at age 50.
Gerardo Andrés Puentes Leal, Marcela Pérez Rodríguez , Esperanza Peña Torres   +2 more
doaj   +1 more source

QALY: Quality Adjusted Life Year

Medicine Science | International Medical Journal, 2012
Nufusun yaslanmasi ve yaslilik donemi hastaliklar ile kronik hastaliklarin one cikmasi verilen saglik hizmetlerinin sadece saglik duzeyi uzerine degil yasam kalitesine etkisinin de onemli bir cikti olarak degerlendirilmesini getirmistir. Aslinda bu yaklasim Dunya Saglik Orgutunun (WHO), 1946 yilinda sagligi “yalnizca hastalik ve sakatligin ...
Selale Sahin, Selime Toprak, Erdinc Unal
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Disability-Adjusted Life Years Averted Versus Quality-Adjusted Life Years Gained: A Model Analysis for Breast Cancer Screening

, 2021
Objectives: To quantify the impact of mammography-based screening on the quality of life, disability-adjusted life years (DALYs) averted or quality-adjusted life years (QALYs) gained can be used.
Segnan, N. (Nereo), Davidović, M. (Maša), Zielonke, N. (Nadine), Lansdorp-Vogelaar, I. (Iris), Koning, H.J. (Harry) de, Heijnsdijk, E.A.M. (Eveline)   +5 more
core   +2 more sources