Results 81 to 90 of about 295,936 (337)

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source

Blue applicability grade index assessment and response surface modelling to synchronous determination of metformin hydrochloride, vildagliptin and dapagliflozin propanediol monohydrate by HPTLC method

Future Journal of Pharmaceutical Sciences
Diabetes mellitus is major chronic disease found in human due to stressful lifestyle and bad food habit. Recently, the Central Drugs Standard Control Organization of India has approved combination of metformin hydrochloride, vildagliptin and ...
Pintu Prajapati, Krutika Patil, Dhrumi Naik, Veera Shakar Pulusu, Anzarul Haque, Mohd Abul Kalam, Shailesh Shah   +6 more
doaj   +1 more source

Analytical method development and validation for simultaneous estimation of mefloquine hydrochloride and artemether in bulk drug by simultaneous equation method

Journal of Applied Pharmaceutical Research, 2020
The purpose of the research is to establish a fast, accurate, precise, and low-cost UV-Visible spectrophotometry method for the quantitative simultaneous estimation of mefloquine hydrochloride and artemether in bulk drug.
Amit Choudhary, Manish Sinha, Amar Deep Ankalgi, Kamya Goyal, Arti Devi   +4 more
doaj   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Software Quality Assurance

, 1986
Quality assurance has been in existence for a long time in many fields of engineering, but in software engineering the idea is still fairly new. In this paper we describe the current state of Software Quality Assurance (SQA), and propose a classification of techniques.
Frühauf, Karol, Ludewig, Jochen, Sandmayr, Helmut   +2 more
openaire   +3 more sources

Green analytical chemistry-based spectrophotometric techniques for ternary component analysis of pain relievers

Future Journal of Pharmaceutical Sciences
Background The management of pain presents a significant challenge in healthcare, particularly in cases where conventional therapies prove inadequate.
Thirumalai Arunagiri, Alagammai Ganesan, Vamsi Ravi Kumaran, Bharathraj Masilamani, Kanaka Parvathi Kannaiah, Damodharan Narayanasamy   +5 more
doaj   +1 more source

Method development and validation for multi-component analysis of lamivudine & tenofovir disoproxil fumarate in bulk drug by UV-visible spectrophotometer & RP-HPLC

Journal of Applied Pharmaceutical Research, 2020
A novel, simple, precise and accurate method developed for the estimation of Lamivudine and tenofovir disoproxil fumarate (TDF) in bulk drug form has been established. Lamivudine and tenofovir are well known drugs and used in treatment of HIV- Ⅰ.
Shweta Sharma, Amar Deep Ankalgi, Pooja Kaushal, M. S. Ashawat   +3 more
doaj   +1 more source

Open Problems in Engineering and Quality Assurance of Safety Critical Machine Learning Systems [PDF]

arXiv, 2018
Fatal accidents are a major issue hindering the wide acceptance of safety-critical systems using machine-learning and deep-learning models, such as automated-driving vehicles. Quality assurance frameworks are required for such machine learning systems, but there are no widely accepted and established quality-assurance concepts and techniques.
arxiv  

The AIQ Meta-Testbed: Pragmatically Bridging Academic AI Testing and Industrial Q Needs [PDF]

arXiv, 2020
AI solutions seem to appear in any and all application domains. As AI becomes more pervasive, the importance of quality assurance increases. Unfortunately, there is no consensus on what artificial intelligence means and interpretations range from simple statistical analysis to sentient humanoid robots.
arxiv