Results 191 to 200 of about 2,583,795 (262)

Quality by Design-Guided Development of Hydrogel-Forming Microneedles for Transdermal Delivery of Enfuvirtide. [PDF]

ACS Appl Mater Interfaces
Li H, Vora LK, Anjani Q, Abraham AM, Cong Y, Moreno-Castellanos N, Ballana E, Riveira Muñoz E, Nevot M, Donnelly RF.   +9 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A quality-by-design optimized LC method for navigating degradation kinetics and quantification of favipiravir in the presence of degradation products and manufacturing impurities. [PDF]

BMC Chem
Ibrahim AE, Farouk M, Alamir SG, Salman BI, Belal TS, El Deeb S, Al-Harrasi A.   +6 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The interpretation-use argument- the essential ingredient for high quality assessment design and validation. [PDF]

Adv Health Sci Educ Theory Pract
Raymond J, Dai DW, McAllister S.
europepmc   +1 more source

Quality by design strategy of human mesenchymal stem/stromal cell drug products for the treatment of knee osteoarthritis. [PDF]

World J Stem Cells
Yu H, Zhang F, He YC, Zhang LS.
europepmc   +1 more source

Quality by Design (QbD)-Based Development of a Self-Nanoemulsifying Drug Delivery System for the Ocular Delivery of Flurbiprofen. [PDF]

Pharmaceutics
Jeong JH, Yoon TH, Ryu SW, Kim MG, Kim GH, Oh YJ, Lee SJ, Kwak NW, Bang KH, Kim KS.   +9 more
europepmc   +1 more source

Development and Optimization of <i>Kunzea ericoides</i> Nanoemulgel Using a Quality by Design Approach for Transdermal Anti-Inflammatory Therapy. [PDF]

Gels
Yetukuri K, Umashankar MS.
europepmc   +1 more source

Quality by design for transient RBD-Fc fusion protein production in Chinese hamster ovary cells. [PDF]

Biotechnol Rep (Amst)
Jivapetthai A, Arunmanee W, Pornputtapong N.   +2 more
europepmc   +1 more source

A Practical Approach to Implementing ICH Q14: Tools for Analytical Quality by Design in Capillary Electrophoresis Method Development. [PDF]

Electrophoresis
Tricht EV, Sänger-van de Griend CE.
europepmc   +1 more source