Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
A hybrid innovation method based on quality by design and agile scrum paradigms for the development of medicinal products. [PDF]
Bastogne T +4 more
europepmc +1 more source
Research on Enhancing the Solubility and Bioavailability of Canagliflozin Using Spray Drying Techniques with a Quality-by-Design Approach. [PDF]
Lee JH +5 more
europepmc +1 more source
Scale-Agnostic Models Based on Dimensionless Quality by Design as Pharmaceutical Development Accelerator. [PDF]
Romero-Obon M +6 more
europepmc +1 more source
Quality by Design Formulation Approach for the Development of Orodispersible Tablets of Dexlansoprazole. [PDF]
Ali AT +10 more
europepmc +1 more source
Optimizing clarification processes in biopharmaceutical manufacturing through quality by design: Strategies, implications, and future prospects. [PDF]
Yeop KW +7 more
europepmc +1 more source
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