Results 191 to 200 of about 3,032,107 (315)

DualSightNet: A novel dual architecture for visual quality control of railway infrastructure. [PDF]

PLoS One
Mai C, Eisentraut L, Ketterer J, Buettner R.   +3 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Quality Control and Regulatory Scientific Research on Collagen-Based Medical Devices. [PDF]

Cell Prolif
Wang R, Shi J, Zhou J, Ke L, Yue C.
europepmc   +1 more source

Data-Driven Robust M-LS-SVR-Based NARX Modeling for Estimation and Control of Molten Iron Quality Indices in Blast Furnace Ironmaking

, 2017
Ping Zhou, Dongwei Guo, Hong Wang, Tianyou Chai   +3 more
openalex   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Impairment of lysosomal quality control in Huntington disease. [PDF]

Cell Death Dis
Rusmini P, Mina F, Valenza M, Vitali M, Ferrari V, Tedesco B, Casarotto E, Cozzi M, Chierichetti M, Mohamed A, Pramaggiore P, Cornaggia L, Milioto C, Brodnanova M, Magdalena R, Koshal P, Piccolella M, Cristofani R, Galbiati M, Crippa V, Poletti A.   +20 more
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

p62/SQSTM1 Condensation Modulates Mitochondrial Clustering to Participate in Mitochondrial Quality Control. [PDF]

Aging Cell
Sun S, Xin J, Zhang Y, Yang B, Su D, Ni R, Ma Q, Li N, Ma G, Peng Q, Chen S, Prehn JHM, Tam KY, Wang H, Ying Z.   +14 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Targeting mitochondrial quality control in diabetic kidney disease: emerging therapeutic opportunities. [PDF]

Ren Fail
Luo J, Lu F, Cuciureanu M, Xu X, Dong H, Gong M.   +5 more
europepmc   +1 more source