Results 121 to 130 of about 467,464 (312)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Data Development Trend of Public/Private Medical Institutions in Chinese Plastic and Aesthetic Major

open access: yesXiehe Yixue Zazhi
ObjectiveTo compare and understand the trends in quality control data changes in public and private medical institutions specializing in plastic and aesthetic major in China over the past three years.MethodsThe national quality control center of plastic ...
ZHANG Mingzi   +6 more
doaj   +1 more source

EFFECTIVENESS ASSESSMENT METHODOLOGY OF INFORMATION SECURITY MANAGEMENT SYSTEM THROUGH THE SYSTEM RESPONSE TIME TO INFORMATION SECURITY INCIDENTS [PDF]

open access: yesНаучно-технический вестник информационных технологий, механики и оптики, 2014
Quality assessment of information security management system is an important step for obtaining baseline data for analysis of the security system control effectiveness, and evaluating implementation of the specified information security requirements of
F. N. Shago
doaj  

Quality Control оf Roadway Bridges - Reliability Assessment

open access: yes, 2018
The elaboration of adequate quality control plans is one of the crucial tasks in bridge management today. This is the topic of the ongoing COST TU1406 action, where it is proposed to control quality focus by means of key performance indicators. To this
Tanasić, Nikola   +3 more
core  

Classification of Performance and Quality Indicators in Manufacturing

open access: yes, 2006
A critical aspect in operations management is to represent the firm goals properly. This is usually done by translating the organisational results and objectives in ‘performance measurements'.
Franceschini, Fiorenzo   +2 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

open access: yesFEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber   +7 more
wiley   +1 more source

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