Results 121 to 130 of about 467,464 (312)
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The human gut microbiome across the life course
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Data Development Trend of Public/Private Medical Institutions in Chinese Plastic and Aesthetic Major
ObjectiveTo compare and understand the trends in quality control data changes in public and private medical institutions specializing in plastic and aesthetic major in China over the past three years.MethodsThe national quality control center of plastic ...
ZHANG Mingzi +6 more
doaj +1 more source
EFFECTIVENESS ASSESSMENT METHODOLOGY OF INFORMATION SECURITY MANAGEMENT SYSTEM THROUGH THE SYSTEM RESPONSE TIME TO INFORMATION SECURITY INCIDENTS [PDF]
Quality assessment of information security management system is an important step for obtaining baseline data for analysis of the security system control effectiveness, and evaluating implementation of the specified information security requirements of
F. N. Shago
doaj
Quality Control оf Roadway Bridges - Reliability Assessment
The elaboration of adequate quality control plans is one of the crucial tasks in bridge management today. This is the topic of the ongoing COST TU1406 action, where it is proposed to control quality focus by means of key performance indicators. To this
Tanasić, Nikola +3 more
core
Classification of Performance and Quality Indicators in Manufacturing
A critical aspect in operations management is to represent the firm goals properly. This is usually done by translating the organisational results and objectives in ‘performance measurements'.
Franceschini, Fiorenzo +2 more
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source

