Results 61 to 70 of about 5,845,653 (299)

The Australian Research Quality Framework: A live experiment in capturing the social, economic, environmental, and cultural returns of publicly funded research [PDF]

, 2008
Copyright @ 2008 Wiley Periodicals Inc. This is the accepted version of the following article: Donovan, C. (2008), The Australian Research Quality Framework: A live experiment in capturing the social, economic, environmental, and cultural returns of ...
Allen Consulting Group, Austrian Science Fund (FWF)/European Science Foundation (ESF), Department of Education, Science and Training (DEST), Department of Education, Science and Training (DEST), Department of Education, Science and Training (DEST), Department of Education, Science and Training (DEST), Department of Education, Science and Training (DEST), Department of Education, Science and Training (DEST), Department of Education, Science and Training (DEST), Department of Education, Science and Training (DEST), Department of Education, Science and Training (DEST), Department of Education, Science and Training (DEST), Department of Education, Science and Training (DEST), Department of Innovation, Industry, Science and Research (IISR), Donovan, Donovan, Donovan, Donovan, Martin, Research Quality Framework Technical Working Group on Research Impact (TWGRI), Spaapen, Wooding   +21 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The Impact on Writing Skills of Tablets in College Developmental English Classes [PDF]

Titre de l'écran-titre (visionné le 14 mai 2013)Disponible en français : Les Répercussions des tablettes électroniques sur les compétences en rédaction dans les cours de perfectionnement en anglais de niveau collégial ...
Higher Education Quality Council of Ontario, Schmitz, Andrew.   +1 more
core  

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

WATER QUALITY EDUCATION [PDF]

Resource /Energy Economics and Policy,
Libby, Lawrence W.
core   +1 more source

Quality of the Preschool Education in the Raihat Subdistrict Belu Regency Nusa Tenggara Timur [PDF]

, 2015
One form of the basic needs of the Ministry became the responsibility of the Government is the aspect of education, especially basic education. Quality education contributing to the welfare of the community improvement efforts refers to the concept of ...
Neolaka, Melkisedek N.B.C., Suwitri, Sri, Warella, Y, Warsono, Hardi   +3 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source