Results 81 to 90 of about 5,845,653 (299)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Research Trends on Digital Literacy in Quality Education: Bibliometric Analysis Form 2000 to 2024

open access: yesJurnal Teknologi Pendidikan
Digital Literacy Although many researchers discuss digital literacy, the contribution of digital literacy research to the quality of education is often fragmented, with diverse and unsystematic topics, approaches, and geographical areas. Therefore, this
Hilhamsyah   +5 more
doaj  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Necesidades de formación de directivos docentes: un estudio en instituciones educativas colombianas Necessidades de formação de diretivos docentes: um estudo em instituições educativas colombianas The Training Needs of Teachers-Administrators: A Study Done at Colombian Schools

open access: yesEducación y Educadores, 2008
El artículo contiene una síntesis de los fundamentos teóricos y metodológicos, y algunos de los resultados obtenidos de una investigación realizada por el grupo de investigación de Educación y Educadores, de la Universidad de La Sabana , sobre la ...
Luz Yolanda Sandoval-Estupiñán   +5 more
doaj  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

EDUCATION FOR QUALITY TOURISM MANAGEMENT

open access: yesTourism and hospitality management, 2009
In every analysis of the economic development of Croatia, education is pointed out as a key factor. With the share of highly educated in the workforce of less than 15 percent, Croatia is seriously lagging behind developed countries. Human resource management (HRM) is a philosophy, a way of thinking for each employee.
Cetinski, Vinka, Sugar, Violeta
openaire   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

A qualitative inquiry of the pedagogical tolerance qualities of heads in higher education institutions

open access: yesCogent Education
This study evaluates the pedagogical tolerance qualities of heads in higher education institutions in Kazakhstan. The qualitative research design, grounded in the interpretative paradigm, was adopted for this study, utilising a case study approach for ...
Baizhuman Kashkhynbay   +4 more
doaj   +1 more source

Editorial: Pursuing quality education in Physical and Rehabilitation Medicine. [PDF]

open access: yesFront Rehabil Sci, 2023
Ceravolo MG, Gimigliano F, Lains J.
europepmc   +1 more source

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