Results 191 to 200 of about 7,065,211 (348)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

High-quality-factor viscoelastic nanomechanical resonators from moiré superlattices. [PDF]

Nat Commun
Zeng QY, Su GX, Song AS, Mei XY, Xu ZY, Ying Y, Zhang ZZ, Song XX, Deng GW, Moser J, Ma TB, Tan PH, Zhang X.   +12 more
europepmc   +1 more source

Highly-twisted states of light from a high quality factor photonic crystal ring. [PDF]

Nat Commun, 2023
Lu X, Wang M, Zhou F, Heuck M, Zhu W, Aksyuk VA, Englund DR, Srinivasan K.   +7 more
europepmc   +1 more source

Factors Affecting Quality Of Care In Primary Health Care Centres With Special Reference To Anuppur District (M.P)

, 2019
Jianguanglung Dangmei, Amarendra Pratap Singh   +1 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Room-temperature valley-selective emission in Si-MoSe₂ heterostructures enabled by high-quality-factor chiroptical cavities. [PDF]

Nat Commun
Pan F, Li X, Johnson AC, Dhuey S, Saunders A, Hu MX, Dixon JP, Dagli S, Lau SC, Weng T, Chen CY, Zeng JH, Apte R, Heinz TF, Liu F, Deng ZL, Dionne JA.   +16 more
europepmc   +1 more source

Effect of Electrode Thickness on Quality Factor of Ring Electrode QCM Sensor. [PDF]

Sensors (Basel), 2022
Wei Z, Hu J, Li Y, Chen J.
europepmc   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Influence of phantom material on the depth-dose profile and radiation quality factor of 126 MeV antiprotons - a FLUKA Monte Carlo study. [PDF]

Radiat Environ Biophys
Chattaraj A, Selvam TP.
europepmc   +1 more source

Space radiation quality factor for Galactic Cosmic Rays and typical space mission scenarios using a microdosimetric approach. [PDF]

Radiat Environ Biophys, 2023
Papadopoulos A, Kyriakou I, Incerti S, Santin G, Nieminen P, Daglis IA, Li W, Emfietzoglou D.   +7 more
europepmc   +1 more source