Results 31 to 40 of about 1,554,048 (268)

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Agrobacterium rhizogenes-mediated stable and transient transformation systems enable rapid functional validation of C6 aldehyde synthesis genes in peach

BMC Plant Biology
Background The established genetic transformation system is essential for gene function research and genetic improvement of horticultural crops. The lack of efficient genetic transformation systems has long been a significant bottleneck for perennial ...
Yike Su, Mengtao Li, Xubin Wu, Bo Zhang, Xiangmei Cao   +4 more
doaj   +1 more source

Beyond the Single Pathogen Paradigm in Citrus: A Pathobiome Perspective on Disease Complexes, Microbiome Dysbiosis, and Management

Plants
Citrus diseases are commonly interpreted within a single pathogen framework, yet increasing evidence shows that disease outcomes can also be shaped by mixed infections, disease-associated microbiome restructuring, host responses, and interactions among ...
Min Luo, Hongyu Zhang, Ting Zhong, Changzhi Xie, Junkang Cheng, Xiaoli Lin, Wei Chen, Qiongbo Hu   +7 more
doaj   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Quality Improvement [PDF]

Stroke, 2021
Monique F. Kilkenny, Dawn M. Bravata
openaire   +2 more sources

Synergistic remediation of arsenite and cadmium co-contaminated water using Fe-Mn oxides modified graphene oxide

Applied Water Science
A novel graphene oxide composite incorporating iron (Fe) and manganese (Mn) (GO-FM) was synthesized by co-precipitating Fe and Mn oxides onto graphene oxide to remediate As3+ and Cd2+ contaminants in water.
Jizi Wu, Jing Yuan, Bin Lian, Feng Yuan, Qiuchan Wu, Qi Sun, Xin Tian, Jie Wang, Keli Zhao   +8 more
doaj   +1 more source

Raw milk from individual teats with an optimal teat-end score has lower spore levels compared with teats with a suboptimal teat-end score

JDS Communications
Udder health in dairy cows is routinely monitored (for example, through determination of SCC) to help identify and control mastitis and other infectious diseases.
Aljoša Trmčić, Rachel L. Evanowski, Sriya Sunil, Martin Wiedmann, Nicole H. Martin   +4 more
doaj   +1 more source

Invited review: Redefining raw milk quality—Evaluation of raw milk microbiological parameters to ensure high-quality processed dairy products

Journal of Dairy Science, 2023
: Raw milk typically has little bacterial contamination as it leaves the udder of the animal; however, through a variety of pathways, it can become contaminated with bacteria originating from environmental sources, the cow herself, and contact with ...
N.H. Martin, R.L. Evanowski, M. Wiedmann
doaj   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source