Results 191 to 200 of about 12,119,388 (349)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Development and 2025 re-evaluation of a Japanese quality indicator set for adult intensive care: a modified RAND/UCLA Delphi study. [PDF]

J Intensive Care
Kumasawa J, Okamoto H, Naito T, Asaga T, Kimura M, Kotani T, Komatsu Y, Suzuki T, Takahashi T, Takei T, Nishimura M, Hashimoto S, Yamaguchi H, Doi M.   +13 more
europepmc   +1 more source

A Neural Network-Based Mesh Quality Indicator for Three-Dimensional Cylinder Modelling. [PDF]

Entropy (Basel), 2022
Chen X, Wang Z, Liu J, Gong C, Pang Y.
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Validity of aerosolization detection with an air quality indicator in noncontact tonometry using corneal phantoms. [PDF]

Front Ophthalmol (Lausanne), 2022
Ibinson JT, Yousefi A, Roberts CJ, Reilly MA.   +3 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Quality indicator survey of clinical practice guidelines for esophagogastric junction cancer 2023. [PDF]

Dis Esophagus
Matsuda S, Wijnhoven B, Lordick F, Bhandari P, Liu F, Kato K, Gotoda T, Ferri L, Takeuchi H, Kakeji Y, Yang HK, Kitagawa Y.   +11 more
europepmc   +1 more source

Pain Assessment in Intensive Care Unit: A Forgotten Entity or a Quality Indicator? [PDF]

Indian J Crit Care Med, 2022
Havaldar AA.
europepmc   +1 more source

Air quality indicators.

, 1998
This report proposes and describes in detail several new methods for describing population exposure. These suggested methods of describing population exposure are a function of temporal, spatial and individual micro-environment movements. The episode is the basic entity, and the AQIs include the duration, the inter-episode period, the peak and the ...
Clench-Aas, Jocelyn, Guerreiro, Cristina, Bartonova, Alena   +2 more
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source