Results 81 to 90 of about 687,925 (260)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Formalised quality indicator and fake patient data

, 2014
Indicator formalised by 8 students and fake patient data (schema might have changed a little) accompanying our paper "The Reproducibility of CLIF, a Method for Clinical Quality Indicator Formalisation".
Kathrin Dentler (452665)
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Stepwise procedure of CS quality indicator development.

, 2016
Stepwise procedure of CS quality indicator development.
Maurice G. A. J. Wouters (846650), Jan G. Nijhuis (168698), Karin de Boer (846635), Det van Dijk (846637), Wilbert A. Spaans (846648), Luc Smits (846647), Frans J. M. E. Roumen (846645), Sander van Kuijk (846641), Hubertina C. J. Scheepers (846652), Anneke Kwee (79280), Ellen Smid-Koopman (846646), Johannes J. Duvekot (283448), Henriëtte Burggraaf (846636), Wim J. van Wijngaarden (168755), Rosella P. M. G. Hermens (846651), Tom H. M. Hasaart (846638), Diny Kolkman (846640), Harry Visser (846649), Jos J. M. van Roosmalen (846644), Sonja Melman (846633), Ben W. Mol (846642), Jeroen van Dillen (737376), Jan B. Derks (175632), Christine Willekes (79279), Mariëlle G. van Pampus (168730), Arie Franx (377859), Carmen D. Dirksen (836080), Anjoke J. M. Huisjes (846639), Ellen C. N. Schoorel (846634), Alieke de Roon-Immerzeel (846643)   +29 more
core   +1 more source

Implications for bachelor of nursing programs when using student experience survey findings as an indicator of course quality

, 2020
Objective: To discuss the implications of using student experience surveys to improve the quality of teaching and learning within bachelor of nursing programs in Australia.
Smith, MR, Henderson, S, Grealish, L
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The quality indicator tool.

Quality indicator contour lines in green, yellow and red, correspond with good, medium and bad quality apical 4 chamber positioning. Republished from [12] under a CC BY license, with permission from GE HealthCare, original copyright 2021.
Oren Wacht (17146645), Itamar Ben Shitrit (15379441), Noam Aronovitz (18272135), Roni Jedwab (18272138), Lior Fuchs (362430), Anna Quinn (9020153), Itai Hazan (14078751)   +6 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Improving quality assessment of composite indicators in university rankings: a case study of French and German universities of excellence [PDF]

Composite indicators play an essential role for benchmarking higher education institutions. One of the main sources of uncertainty building composite indicators and, undoubtedly, the most debated problem in building composite indicators is the weighting ...
Monica Benito, Rosario Romera
core