Results 251 to 260 of about 1,130,607 (302)

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Defining quality indicators for atherosclerotic cardiovascular diseases in primary care, extractable from the electronic health record: a RAND-modified Delphi method. [PDF]

BMC Prim Care
Christiaens L, Raat W, Meel L, Avonts M, Van de Putte M, Vaes B, Van den Bulck S.   +6 more
europepmc   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Defining success together: a collaborative approach for client and provider-engaged outcomes indicator development in Ontario. [PDF]

Res Involv Engagem
Perri M, Rudzinski K, Guta A, Xavier J, Kolla G, Carusone SC, Strike C.   +6 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Indicators for effective glaucoma care coverage in adults: protocol for a scoping review. [PDF]

BMJ Open
Matayan EY, Burn H, Gordon I, Evans J, Toews I, Ramke J, Burton MJ, Philippin H, Mtuy T, Hu VH.   +9 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Structural analysis of nursing quality issues in tertiary hospitals based on quality control inspections: a case study of 59 hospitals in Shanghai. [PDF]

Front Public Health
Cheng Y, Jiang Y, Tai R, Yang L, Xiang Q, Wang Y, Liu Y, Sheng Y, Shi Y, Wang L.   +9 more
europepmc   +1 more source

Development of nursing quality evaluation indicators for extracorporeal membrane oxygenation based on Donabedian theory: A Delphi study. [PDF]

PLoS One
Yu X, Zou H, Tong S, Zhang Y, Tian Z, Zhu S.   +5 more
europepmc   +1 more source