Results 101 to 110 of about 5,207,310 (345)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Quality management system

Enevate incorporates a QMS and pursues a certification according to EN ISO 9001. This ensures high standards and provides transparency for potential customers.
  +6 more sources

Unequal socioeconomic exposure to drought extremes induced by stratospheric aerosol injection [PDF]

Atmospheric Chemistry and Physics
As global temperature rises, the severity and frequency of droughts are projected to increase. Stratospheric aerosol injection (SAI) has been proposed as a potential solution to reduce surface temperatures, but its effectiveness in alleviating drought ...
W. Fu, X. Yue, C. Tian, R. Xu, Y. Guo
doaj   +1 more source

Evaluation of quality management systems implementation in medical diagnostic laboratories benchmarked for accreditation [PDF]

, 2015
Selvi Manickam Tamil, Srinivas Ankanagari   +1 more
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Implementation of a quality management system in a liver transplant programme. [PDF]

BMJ Open Qual, 2023
López-Púa Y, Navasa M, Trilla A, Colmenero J, García R, López E, Durà A, Guash A, Ríos J.   +8 more
europepmc   +1 more source

IT Systems in Aid of Welding Processes Quality Management in the Automotive Industry [PDF]

, 2016
Monika Restecka, Radosław Wolniak
openalex   +1 more source

Montefiore Medical Center: Integrated Care Delivery for Vulnerable Populations [PDF]

, 2010
Describes a system of hospitals and community- and school-based clinics tailored to low-income patients through systemwide strategies, high-quality specialty and hospital care, and integrated care delivery via care management and information ...
Deborah Chase
core  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

The International Quality Systems Environment [PDF]

Enterprises in the agri-food sector are increasingly confronted with the need to adjust their production processes and operations to the requirements of quality systems and to integrate these requirements into their own individual integrated process ...
Krieger, Stephanie, Schiefer, Gerhard
core   +1 more source