Results 71 to 80 of about 617,867 (260)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Association between foot morphology and dynamic knee valgus during single leg squats in recreational male football players: a cross-sectional study

Human Movement
Purpose This study examines the relationship between foot morphology, foot type, and dynamic knee valgus in male football players during single-leg squats using biomechanical analyses. Methods A cross-sectional study design was adopted.
Vinosh Kumar Purushothaman, Noorul Uyoon Ahmed Ibrahim Didi, Ambusam Subramaniam, Arun Vijay Subbarayalu, Sivasankar Prabaharan, Mariam Ameer, Ajmal Sheriff, Arun Prathap, Palanivel Rubavathi Marimuthu   +8 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

THE EFFECT OF QUALITY OF SCHOOL LIFE AND RESILIENCE ON ACADEMIC STRESS IN STUDENTS

Jurnal Psikologi Integratif, 2020
This study aimed to test empirically the effect of quality of school life and resilience on academic stress in university students. The subjects of this study were bachelor degree students of Semarang’s Walisongo Islamic State University, who were in their second to eighth semester.
Muhammad Usman Asy’ari, Baidi Bukhori, Lift Anis Ma’shumah   +2 more
openaire   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Quality of Life of Academic Dentists’ Families; a Cross-Sectional Survey

International Archives of Medicine, 2016
Background and objectives Quality of the social family of dentists has not been given much attention in literature. Further, the quality of dental academics’ families has never been investigated before. The aim of this study is to assess some aspects of the quality of life among academic dentists’ families and to investigate the factors that may ...
Ibrahim Nourwali, Osama Abu-Hammad, Najla S. Dar-Odeh   +2 more
openaire   +2 more sources

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

National Survey on the importance of sleep in the quality of academic life and mental health of college students in Portugal. [PDF]

Sleep Sci, 2021
Reis M, Ramiro L, Paiva T, Gaspar-de-Matos M.   +3 more
europepmc   +1 more source