Results 101 to 110 of about 166,612,573 (299)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Study of Molecular Mechanism of Antibiotic susceptibility against Polymicrobial Oral infection [PDF]

, 2010
Introduction- Antibiotic to treat dental caries infection are routinely prescribed. Bacteria have increased resistance to the currently recommended antibiotics.
Deepak Dwivedi
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Patient Knowledge and Antibiotic Abuse: Evidence from an Audit Study in China [PDF]

We ask how patient knowledge of appropriate antibiotic usage affects both physicians prescribing behavior and the physician-patient relationship. We conduct an audit study in which a pair of simulated patients with identical flu-like complaints visits ...
Wei Zhang, Janet Currie, Wanchuan Lin
core  

PROBLEM OF ANTIBIOTIC USE AND ANTIMICROBIAL RESISTANCE IN INDONESIA: ARE WE REALLY MAKING PROGRESS?

Indonesian Journal of Tropical and Infectious Disease, 2013
Background: Based on the results Antimicrobial Resistance in Indonesia: prevalence and prevention-study (AMRIN-study), the Ministry of Health of Indonesia in 2005 began a program antibiotic resistance control (PPRA) in some government hospitals, and is ...
Usman Hadi, Kuntaman Kuntaman, Mariyatul Qiptiyah, Hari Paraton   +3 more
doaj   +1 more source

Analysis of the Quality of Antibiotic Use in Pediatric Inpatients with Bronchopneumonia

Media Farmasi Indonesia
Bronchopneumonia is lobular pneumonia characterized by the presence of infected areas with spots approximately 3-4 cm in diameter surrounding and involving the bronchi. The improper selection of antibiotics can lead to bacterial resistance and high treatment costs due to prolonged hospital stays. The aim of the study is to determine the appropriateness
Intan Sari, Sri Haryanti, Budi Raharjo
openaire   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Economics of Informed Antibiotic Management and Judicious Use Policies in Animal Agriculture [PDF]

Antibiotic effectiveness can be viewed as a biological commons since current use may decrease future effectiveness. The value of the biological commons declines when the targeted bacteria develop antibiotic resistance.
Jia, Yanan, Feng, Hongli, Hennessy, David   +2 more
core  

Control strategies to prevent total hip replacement-related infections: a systematic review and mixed treatment comparison [PDF]

, 2014
Objective: To synthesise the available evidence and estimate the comparative efficacy of control strategies to prevent total hip replacement (THR)-related surgical site infections (SSIs) using a mixed treatment comparison.\ud Design: Systematic review ...
Cooper, N, H. Zheng (2057848), K. Merollini (7697756), Merollini, Katharina, Wilson, Jennie, Zheng, H, Berendt, T, Graves, Nicholas, Wilson, Jennie A., Nicola Cooper (698917), T. Berendt (7697759), Berendt, Tony, Zheng, Henry, Barnett, Adrian G., Sutton, A, Cooper, Nicola, J. Wilson (4917331), Barnett, A G, A. G. Barnett (7697753), Alex Sutton (11700), Graves, N, Wilson, J, N. Graves (7697762), Zhang, Henry, Sutton, Alex   +24 more
core   +2 more sources