Results 111 to 120 of about 166,612,573 (299)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Monopoly Pricing of an Antibiotic Subject to Bacterial Resistance [PDF]
We develop a dynamic bio-economic model of bacterial resistance and disease transmission in which we characterize the pricing policy of a monopolist who is protected by a patent.
Markus Herrmann
core
Detection and characterisation of genes encoding antibiotic resistance in the cultivable oral microflora. [PDF]
, 2006 The emergence of antibiotic-resistant bacteria has become a major threat to public health. The increased use of antibiotics has selected for the dissemination of antibiotic resistance genes between organisms from different species and different genera ...
Villedieu, A., Villedieu, Aurelie
core
Streamlining antibiotic use in community acquired pneumonia: A quality improvement initiative
Journal of Hospital MedicineAbstract Background Evidence suggests a 3‐day total duration and early transition to oral therapy is safe in hospitalized patients with community acquired pneumonia (CAP)—though such care is not standard in the United States.
Claire E. Ciarkowski +6 more
openaire +2 more sources
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Antibiotic prescribing on two medical wards at St Luke’s Hospital : what scope for improvement? [PDF]
, 1996 Antibiotics are frequently prescribed drugs and form a significant part of the hospital budget. The literature suggests that prescribing is not without problems and may need constant review. We have no data relating to our hospital.
Fenech, Frederick F. +3 more
core
Antibiotic use in Albania between 2011 and 2012
Journal of Infection in Developing Countries, 2015 Introduction: Health institutions in Albania have recently reported an increase in antibiotic misuse and microbial resistance. Until now, there have been no comprehensive studies that analyzed the overall use of antibiotics in Albania.
Iris Hoxha, Admir Malaj, Ledjan Malaj
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Antibiotic resistance in the environment, with particular reference to MRSA [PDF]
, 2008 The introduction of β-lactam antibiotics (penicillins and cephalosporins) in the 1940s and 1950s probably represents the most dramatic event in the battle against infection in human medicine.
William Gaze +13 more
core +1 more source